K Abram1, H Silm, H-I Maaroos, M Oona. 1. Clinic of Dermatology, University of Tartu, Tartu, Estonia. kristi.abram@kliinikum.ee
Abstract
BACKGROUND: Although rosacea is a common disease, the cause of disease is still a mystery -Helicobacter pylori infection, genetic predisposition, climatic factors, and detrimental habits are implicated as triggers of rosacea. OBJECTIVE: The aim of current study is to evaluate several suspected risk factors coincidently. METHODS: Patients with rosacea from a dermatology clinic and skin-healthy controls from an randomly selected employees' population enrolled the study. Skin status were evaluated by one and same dermatologist. Participants were queried for age, gender, sun-reactive skin type, and detrimental habits using a questionnaire; blood samples for detecting Helicobacter pylori serostatus were collected. RESULTS: Totally 145 skin-healthy controls and 172 subjects either with flushing episodes or established rosacea included the study. In multivariate analysis, rosacea patients had significantly higher chance to have photosensitive skin types (OR 1.75; 95% CI 1.01-3.04; P < 0.05), positive family history to rosacea (OR 4.31; 95% CI 2.34-7.92; P < 0.0001) or previous smoking status (OR 2.01; 95% CI 1.07-3.80; P < 0.05) comparing with skin-healthy controls. There were no statistically significant differences either in gender, Helicobacter pylori serostatus, caffeine intake, alcohol consumption, occupational environment, or education level between rosacea patients and controls. CONCLUSION: Rosacea is foremost associated with familial predisposition. There is no association between Helicobacter pylori infection and rosacea in current study.
BACKGROUND: Although rosacea is a common disease, the cause of disease is still a mystery -Helicobacter pyloriinfection, genetic predisposition, climatic factors, and detrimental habits are implicated as triggers of rosacea. OBJECTIVE: The aim of current study is to evaluate several suspected risk factors coincidently. METHODS:Patients with rosacea from a dermatology clinic and skin-healthy controls from an randomly selected employees' population enrolled the study. Skin status were evaluated by one and same dermatologist. Participants were queried for age, gender, sun-reactive skin type, and detrimental habits using a questionnaire; blood samples for detecting Helicobacter pylori serostatus were collected. RESULTS: Totally 145 skin-healthy controls and 172 subjects either with flushing episodes or established rosacea included the study. In multivariate analysis, rosaceapatients had significantly higher chance to have photosensitive skin types (OR 1.75; 95% CI 1.01-3.04; P < 0.05), positive family history to rosacea (OR 4.31; 95% CI 2.34-7.92; P < 0.0001) or previous smoking status (OR 2.01; 95% CI 1.07-3.80; P < 0.05) comparing with skin-healthy controls. There were no statistically significant differences either in gender, Helicobacter pylori serostatus, caffeine intake, alcohol consumption, occupational environment, or education level between rosaceapatients and controls. CONCLUSION:Rosacea is foremost associated with familial predisposition. There is no association between Helicobacter pyloriinfection and rosacea in current study.
Authors: Bo Young Chung; Hye One Kim; Chun Wook Park; Na Gyeong Yang; Jae Yun Kim; Yun Su Eun; Euy Hyun Chung; Sung Yul Lee; Young Lip Park; Sang Hoon Lee; Nam Hun Heo; Min Jeong Shin; Jung Eun Kim Journal: Biomed Res Int Date: 2022-07-04 Impact factor: 3.246
Authors: Suyun Li; Michael L Chen; Aaron M Drucker; Eunyoung Cho; Hao Geng; Abrar A Qureshi; Wen-Qing Li Journal: JAMA Dermatol Date: 2018-12-01 Impact factor: 10.282