| Literature DB >> 19874242 |
Yoshifumi Shinmei1, Haruna Yano, Yoto Kagawa, Kana Izawa, Masaaki Akagi, Toshio Inoue, Chiaki Kamei.
Abstract
We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose. Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.Entities:
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Year: 2009 PMID： 19874242 DOI： 10.3109/08923970903078443
Source DB: PubMed Journal: Immunopharmacol Immunotoxicol ISSN： 0892-3973 Impact factor: 2.730