Zulkuf Kaya1, Muhammed Yayla2, Arzu Bilen3, Nihal Efe Atilla4, Sevilay Ozmen5, Irfan Cinar2, Zafer Bayraktutan6, Vahit Mutlu1, Harun Un7, Erdem Toktay8. 1. Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey. 2. Department of Pharmacology, Kafkas University School of Medicine, Kars, Turkey. 3. Department of Internal Medicine, Ataturk University School of Medicine, Erzurum/Turkey. 4. Department of Otorhinolaryngology, Head and Neck Surgery, Erzurum Training and Research Hospital, Erzurum, Turkey. 5. Department of Pathology, Ataturk University School of Medicine, Erzurum, Turkey. 6. Department of Biochemistry, Ataturk University School of Medicine Erzurum, Turkey. 7. Department of Biochemistry, Agri Ibrahim Cecen University School of Pharmacy, Ağrı, Turkey. 8. Department of Histology and Embriology, Ataturk University School of Medicine, Erzurum, Turkey.
Abstract
OBJECTIVE: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. MATERIALS AND METHODS: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. RESULTS: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups. CONCLUSION: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.
OBJECTIVE: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. MATERIALS AND METHODS: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. RESULTS: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups. CONCLUSION: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.
Authors: Jean Bousquet; Françoise Neukirch; Philippe J Bousquet; Pierre Gehano; Jean Michel Klossek; Martine Le Gal; Bashar Allaf Journal: J Allergy Clin Immunol Date: 2005-12-02 Impact factor: 10.793
Authors: Kiyoshi Takayama; Guillermo García-Cardena; Galina K Sukhova; Jason Comander; Michael A Gimbrone; Peter Libby Journal: J Biol Chem Date: 2002-09-04 Impact factor: 5.157