Literature DB >> 19871544

IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : II. PROPERTIES OF THE BLOOD GROUP A SUBSTANCE FROM POOLS OF HOO STOMACHS AND OF SPECIFIC PRECIPITATES COMPOSED OF "A" SUBSTANCE AND HOMOLOGOUS HUMAN ANTIBODY.

E A Kabat1, A Bendich, A E Bezer.   

Abstract

1. The microquantitative precipitin method can be used to compare the relative activity of different preparations of the blood group A substance from hog stomachs and to study the effect of chemical treatment upon its stability. 2. With samples of about 25 microg. antibody nitrogen, an error of +/-1.7 microg. antibody nitrogen will result in an error of +/-12 per cent in the estimation of the amount of A substance. 3. The blood group A substance showed no significant loss of activity at 37 degrees C. after 48 hours at pH 1.07 to 10.7 or after 2 hours at 100 degrees C. over a pH range from 2.97 to 7.58. Exposure at 100 degrees C. at pH 1.03 or at 9.03 or higher resulted in loss of activity. Parallel results were obtained by the hemagglutination inhibition and quantitative precipitin methods. 4. The solubility of specific precipitates of the blood group A substance from hog stomach and its homologous antibody formed in man was found to be about 1.6 microg. antibody N/ml. 5. A comparison is given of the chemical properties and activity of blood group A substances obtained by several procedures from pools of hog stomachs.

Entities:  

Year:  1946        PMID： 19871544      PMCID： PMC2135588     

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  Disodium-Citrate-Glucose Mixture as a Blood Preservative.

Authors:  J F Loutit; P L Mollison
Journal:  Br Med J       Date:  1943-12-11

2.  QUANTITATIVE ABSOLUTE METHODS IN THE STUDY OF ANTIGEN-ANTIBODY REACTIONS.

Authors:  M Heidelberger
Journal:  Bacteriol Rev       Date:  1939-06

3.  Studies in immunochemistry: 7. The isolation from hog gastric mucin of the polysaccharide-amino acid complex possessing blood group A specificity.

Authors:  W T Morgan; H K King
Journal:  Biochem J       Date:  1943       Impact factor: 3.857

4.  THE IMMUNE RESPONSE OF HUMAN BEINGS TO BRIEF INFECTIONS WITH PNEUMOCOCCUS.

Authors:  M Heidelberger; D G Anderson
Journal:  J Clin Invest       Date:  1944-09       Impact factor: 14.808

5.  QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS.

Authors:  M Heidelberger; C F Macpherson
Journal:  Science       Date:  1943-04-30       Impact factor: 47.728

6.  A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY.

Authors:  M Heidelberger; F E Kendall
Journal:  J Exp Med       Date:  1935-10-31       Impact factor: 14.307

7.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : I. ESTIMATION OF A AND B ISOANTIBODIES IN HUMAN SERUM BY THE QUANTITATIVE PRECIPITIN METHOD.

Authors:  E A Kabat; A E Bezer
Journal:  J Exp Med       Date:  1945-09-01       Impact factor: 14.307

8.  A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : V. THE REACTION BETWEEN CRYSTALLINE HORSE SERUM ALBUMIN AND ANTIBODY FORMED IN THE RABBIT.

Authors:  E A Kabat; M Heidelberger
Journal:  J Exp Med       Date:  1937-07-31       Impact factor: 14.307

9.  A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : IV. THE REACTION OF PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES WITH HOMOLOGOUS RABBIT ANTISERA.

Authors:  M Heidelberger; F E Kendall
Journal:  J Exp Med       Date:  1937-04-30       Impact factor: 14.307

10.  A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : VI. THE REACTION BETWEEN MAMMALIAN THYROGLOBULINS AND ANTIBODIES TO HOMOLOGOUS AND HETEROLOGOUS PREPARATIONS.

Authors:  H E Stokinger; M Heidelberger
Journal:  J Exp Med       Date:  1937-07-31       Impact factor: 14.307
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  9 in total

1.  [Fucose containing mucins predominantly of entodermal origin with blood group and other biological characteristics].

Authors:  G F SPRINGER
Journal:  Klin Wochenschr       Date:  1955-04-15

2.  The human ABO blood group substances.

Authors:  W T J MORGAN
Journal:  Experientia       Date:  1947-07-15

3.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : III. PROPERTIES OF PURIFIED BLOOD GROUP A SUBSTANCES FROM INDIVIDUAL HOG STOMACH LININGS.

Authors:  A Bendich; E A Kabat; A E Bezer
Journal:  J Exp Med       Date:  1946-05-31       Impact factor: 14.307

4.  Immunochemical studies on blood groups; specific precipitation of the fucose of hog and human blood group A substances by anti-A.

Authors:  E A KABAT; H BAER; V KNAUB
Journal:  J Exp Med       Date:  1949-01       Impact factor: 14.307

5.  Immunochemical studies on blood groups; chemical changes associated with destruction of blood group activity and enhancement of the type XIV cross-reactivity by partial hydrolysis of hog and human blood group A, B, and O substances.

Authors:  E A KABAT; H BAER
Journal:  J Exp Med       Date:  1948-07       Impact factor: 14.307

6.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XI. SPECIES DIFFERENCES AMONG BLOOD GROUP A SUBSTANCES.

Authors:  E A Kabat; H Baer; R L Day; V Knaub
Journal:  J Exp Med       Date:  1950-03-31       Impact factor: 14.307

7.  Immunochemical studies on blood groups; the cross reaction between type XIV antipneumococcal horse serum and purified blood group A, B, and O substances from hog and human sources.

Authors:  E A KABAT; A BENDICH
Journal:  J Exp Med       Date:  1948-04-01       Impact factor: 14.307

8.  IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : IV. PREPARATION OF BLOOD GROUP A SUBSTANCES FROM HUMAN SOURCES AND A COMPARISON OF THEIR CHEMICAL AND IMMUNOCHEMICAL PROPERTIES WITH THOSE OF THE BLOOD GROUP A SUBSTANCE FROM HOG STOMACH.

Authors:  E A Kabat; A Bendich; A E Bezer; S M Beiser
Journal:  J Exp Med       Date:  1947-05-31       Impact factor: 14.307

9.  The nature of the virus receptors of red cells; partial purification of the virus agglutination inhibitor in human plasma.

Authors:  G K HIRST
Journal:  J Exp Med       Date:  1949-02       Impact factor: 14.307
  9 in total

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