CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VI. THE SYNTHESIS OFp-AMINOPHENOLalpha-GLUCOSIDE AND ITS COUPLING WITH PROTEIN.

1. The synthesis of p-aminophenol alpha-glucoside has been described. This glucoside can be coupled to any protein to yield a synthetic alpha-glucoside-protein complex. 2. A synthetic beta-glucoside-protein complex has also been prepared. 3. These synthetic sugar-protein complexes have been used as immunizing antigens in order to ascertain whether alpha- and beta-glucosidic unions influence the specificity of the immune response in animals. The results of the immunological studies are presented in the following paper.