Literature DB >> 19865689

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.

Carmen Nájera1, José M Sansano.   

Abstract

In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.

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Year:  2009        PMID： 19865689     DOI： 10.1039/b913066g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

1.  One-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azides with alkynes formed by a Sonogashira cross-coupling and desilylation.

Authors:  Frédéric Friscourt; Geert-Jan Boons
Journal:  Org Lett       Date:  2010-11-05       Impact factor: 6.005

2.  Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor.

Authors:  María Martín-Rodríguez; Carmen Nájera; José M Sansano; Abel de Cózar; Fernando P Cossío
Journal:  Beilstein J Org Chem       Date:  2011-07-19       Impact factor: 2.883

3.  [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds.

Authors:  Sonali Verma; Johnson George; Saurabh Singh; Pushpa Pardasani; Ramchand Pardasani
Journal:  Org Med Chem Lett       Date:  2011-09-06

4.  Determination of Acid Dissociation Constants (pK a ) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent.

Authors:  Yahya Nural; H Ali Döndaş; Hayati Sarı; Hasan Atabey; Samet Belveren; Müge Gemili
Journal:  Int J Anal Chem       Date:  2014-03-30       Impact factor: 1.885

5.  Enantiomerically Enriched 1,2-P,N-Bidentate Ferrocenyl Ligands for 1,3-Dipolar Cycloaddition and Transfer Hydrogenation Reactions.

Authors:  Irina A Utepova; Polina O Serebrennikova; Marina S Streltsova; Alexandra A Musikhina; Tatiana G Fedorchenko; Oleg N Chupakhin; Andrey P Antonchick
Journal:  Molecules       Date:  2018-05-30       Impact factor: 4.411

6.  Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues.

Authors:  Iwona E Głowacka; Jan Balzarini; Graciela Andrei; Robert Snoeck; Dominique Schols; Dorota G Piotrowska
Journal:  Bioorg Med Chem       Date:  2014-05-20       Impact factor: 3.641

7.  Synthesis of spiro[4.4]thiadiazole derivatives via double 1,3-dipolar cycloaddition of hydrazonyl chlorides with carbon disulfide.

Authors:  Kai-Kai Wang; Yan-Li Li; Dong-Guang Guo; Peng-Tao Pan; Aili Sun; Rongxiang Chen
Journal:  RSC Adv       Date:  2021-05-21       Impact factor: 4.036

8.  Isolation of bis(copper) key intermediates in Cu-catalyzed azide-alkyne "click reaction".

Authors:  Liqun Jin; Daniel R Tolentino; Mohand Melaimi; Guy Bertrand
Journal:  Sci Adv       Date:  2015-06-12       Impact factor: 14.136
  8 in total

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