Literature DB >> 19865657

Bromomaleimides: new reagents for the selective and reversible modification of cysteine.

Lauren M Tedaldi1, Mark E B Smith, Ramiz I Nathani, James R Baker.   

Abstract

Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.

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Year:  2009        PMID： 19865657     DOI： 10.1039/b915136b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Emerging synthetic approaches for protein-polymer conjugations.

Authors:  Rebecca M Broyer; Gregory N Grover; Heather D Maynard
Journal:  Chem Commun (Camb)       Date:  2011-01-12       Impact factor: 6.222

2.  Tunable degradation of maleimide-thiol adducts in reducing environments.

Authors:  Aaron D Baldwin; Kristi L Kiick
Journal:  Bioconjug Chem       Date:  2011-09-26       Impact factor: 4.774

3.  Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.

Authors:  Christine A Ott; Bolormaa Baljinnyam; Alexey V Zakharov; Ajit Jadhav; Anton Simeonov; Zhihao Zhuang
Journal:  ACS Chem Biol       Date:  2017-08-24       Impact factor: 5.100

Review 4.  Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications.

Authors:  Xiaoran Roger Liu; Mengru Mira Zhang; Michael L Gross
Journal:  Chem Rev       Date:  2020-04-22       Impact factor: 60.622

5.  A photoisomerization-coupled asymmetric Stetter reaction: application to the total synthesis of three diastereomers of (-)-cephalimysin A.

Authors:  Stephen P Lathrop; Tomislav Rovis
Journal:  Chem Sci       Date:  2013-04       Impact factor: 9.825

6.  In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

Authors:  Felix F Schumacher; Muriel Nobles; Chris P Ryan; Mark E B Smith; Andrew Tinker; Stephen Caddick; James R Baker
Journal:  Bioconjug Chem       Date:  2011-01-27       Impact factor: 4.774

7.  Bromomaleimide-linked bioconjugates are cleavable in mammalian cells.

Authors:  Paul Moody; Mark E B Smith; Chris P Ryan; Vijay Chudasama; James R Baker; Justin Molloy; Stephen Caddick
Journal:  Chembiochem       Date:  2011-11-18       Impact factor: 3.164

8.  Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.

Authors:  Chris P Ryan; Mark E B Smith; Felix F Schumacher; Dina Grohmann; Danai Papaioannou; Gabriel Waksman; Finn Werner; James R Baker; Stephen Caddick
Journal:  Chem Commun (Camb)       Date:  2011-04-05       Impact factor: 6.222

9.  Bromopyridazinedione-mediated protein and peptide bioconjugation.

Authors:  Vijay Chudasama; Mark E B Smith; Felix F Schumacher; Danai Papaioannou; Gabriel Waksman; James R Baker; Stephen Caddick
Journal:  Chem Commun (Camb)       Date:  2011-07-07       Impact factor: 6.222

10.  Protein modification, bioconjugation, and disulfide bridging using bromomaleimides.

Authors:  Mark E B Smith; Felix F Schumacher; Chris P Ryan; Lauren M Tedaldi; Danai Papaioannou; Gabriel Waksman; Stephen Caddick; James R Baker
Journal:  J Am Chem Soc       Date:  2010-02-17       Impact factor: 15.419
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