Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.

Literature DB >> 19864415

A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.

Morgann C Reilly¹, Steven B Levery², Sherry A Castle³, J Stacey Klutts⁴, Tamara L Doering⁵.

Abstract

Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces a distinctive polysaccharide capsule that is necessary for its virulence, a predominantly polysaccharide cell wall, and a variety of protein- and lipid-linked glycans. The glycan synthetic pathways of this pathogen are of great interest. Here we report the detection of a novel glycosylphosphotransferase activity in C. neoformans, identification of the corresponding gene, and characterization of the encoded protein. The observed activity is specific for UDP-xylose as a donor and for mannose acceptors and forms a xylose-alpha-1-phosphate-6-mannose linkage. This is the first report of a xylosylphosphotransferase activity in any system.

Entities: Chemical Species

Mesh：

Substances：

Year: 2009 PMID： 19864415 PMCID： PMC2794727 DOI： 10.1074/jbc.M109.056226

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

42 in total

Review 1. Molecular analysis of the GlcNac-1-phosphotransferase.

Authors: T Braulke; S Pohl; S Storch
Journal: J Inherit Metab Dis Date: 2008-04-15 Impact factor: 4.982

2. Geographic distribution of mating type alleles of Cryptococcus neoformans in four areas of the United States.

Authors: Zhun Yan; Xiaogang Li; Jianping Xu
Journal: J Clin Microbiol Date: 2002-03 Impact factor: 5.948

3. Genetic and phenotypic characterization of capsule mutants of Cryptococcus neoformans.

Authors: E S Jacobson; D J Ayers; A C Harrell; C C Nicholas
Journal: J Bacteriol Date: 1982-06 Impact factor: 3.490

4. The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases.

Authors: John Samuelson; Sulagna Banerjee; Paula Magnelli; Jike Cui; Daniel J Kelleher; Reid Gilmore; Phillips W Robbins
Journal: Proc Natl Acad Sci U S A Date: 2005-01-21 Impact factor: 11.205

5. Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation.

Authors: J C Edman; K J Kwon-Chung
Journal: Mol Cell Biol Date: 1990-09 Impact factor: 4.272

6. The alpha- and beta-subunits of the human UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase [corrected] are encoded by a single cDNA.

Authors: Mariko Kudo; Ming Bao; Anil D'Souza; Fu Ying; Huaqin Pan; Bruce A Roe; William M Canfield
Journal: J Biol Chem Date: 2005-08-24 Impact factor: 5.157

7. Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67.

Authors: V V Vaishnav; B E Bacon; M O'Neill; R Cherniak
Journal: Carbohydr Res Date: 1998-01 Impact factor: 2.104

8. The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid.

Authors: Christian Heiss; J Stacey Klutts; Zhirui Wang; Tamara L Doering; Parastoo Azadi
Journal: Carbohydr Res Date: 2009-03-10 Impact factor: 2.104

9. Comparison of the electrophoretic karyotypes and chromosomal location of ten genes in the two varieties of Cryptococcus neoformans.

Authors: B L Wickes; T D Moore; K J Kwon-Chung
Journal: Microbiology Date: 1994-03 Impact factor: 2.777

10. Decreased virulence in stable, acapsular mutants of cryptococcus neoformans.

Authors: R A Fromtling; H J Shadomy; E S Jacobson
Journal: Mycopathologia Date: 1982-07-23 Impact factor: 2.574

13 in total

1. Gene Regulatory Networks for the Haploid-to-Diploid Transition of Chlamydomonas reinhardtii.

Authors: Sunjoo Joo; Yoshiki Nishimura; Evan Cronmiller; Ran Ha Hong; Thamali Kariyawasam; Ming Hsiu Wang; Nai Chun Shao; Saif-El-Din El Akkad; Takamasa Suzuki; Tetsuya Higashiyama; Eonseon Jin; Jae-Hyeok Lee
Journal: Plant Physiol Date: 2017-07-14 Impact factor: 8.340

2. A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.

Authors: Morgann C Reilly; Kazuhiro Aoki; Zhuo A Wang; Michael L Skowyra; Matthew Williams; Michael Tiemeyer; Tamara L Doering
Journal: J Biol Chem Date: 2011-05-23 Impact factor: 5.157

3. Efficient implementation of RNA interference in the pathogenic yeast Cryptococcus neoformans.

Authors: Indrani Bose; Tamara L Doering
Journal: J Microbiol Methods Date: 2011-04-29 Impact factor: 2.363

4. Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition.

Authors: Yi Qian; Eline van Meel; Heather Flanagan-Steet; Alex Yox; Richard Steet; Stuart Kornfeld
Journal: J Biol Chem Date: 2014-12-11 Impact factor: 5.157