BACKGROUND: In obese patients, positioning of the BioEnterics intragastric balloon (BIB) proved beneficial for weight loss, but the effect of the device on ameliorating some components of the metabolic syndrome associated with obesity remains uncertain. OBJECTIVE: To evaluate the effectiveness of BIB insertion on weight control and amelioration of components of the metabolic syndrome. DESIGN: A prospective intervention study performed at baseline, 6 months after BIB insertion, and after a mean (standard deviation [SD]) of 21 (3) months (range 14-26) of follow-up. SETTING: Division of Gastroenterology and Endoscopic Unit, "Casa Sollievo della Sofferenza" Hospital. PATIENTS: One hundred thirty obese patients with a mean (SD) weight of 118 (24) kg and mean (SD) body mass index (BMI) of 43 (8) kg/m(2). INTERVENTIONS: Positioning of BIB. MAIN OUTCOME MEASUREMENTS: Anthropometric and laboratory parameters. RESULTS: Overall, the mean (SD) weight and BMI decreased by 13.2 (8.2) kg and 5.1 (3.2) kg/m(2), respectively, compared with baseline. The mean glycemia, insulinemia, Homeostasis Model Assessment index, triglyceridemia, and alanine aminotransferase levels were significantly reduced. In the 91 responders (BMI decrease of > or = 3.5 kg/m(2)), the mean (SD) weight and BMI decreased by 16.4 (6.3) kg and 6.4 (2.3) kg/m(2), respectively, and severe liver steatosis decreased from 52% to 4% (P < .0001). On multivariate analysis, severe steatosis and the Homeostasis Model Assessment index were predictive of the response to BIB: odds ratios of 6.71 (95% CI, 2.23-20.19) and 3.18 (95% CI, 1.20-8.42). After a median follow-up of 22 months after BIB removal, 50% of responders maintained or continued to lose weight. LIMITATIONS: No sham-treated patients were included as comparative controls. CONCLUSIONS: Treatment was effective in inducing weight loss, improving liver steatosis, and restoring some components of the metabolic syndrome. 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
BACKGROUND: In obesepatients, positioning of the BioEnterics intragastric balloon (BIB) proved beneficial for weight loss, but the effect of the device on ameliorating some components of the metabolic syndrome associated with obesity remains uncertain. OBJECTIVE: To evaluate the effectiveness of BIB insertion on weight control and amelioration of components of the metabolic syndrome. DESIGN: A prospective intervention study performed at baseline, 6 months after BIB insertion, and after a mean (standard deviation [SD]) of 21 (3) months (range 14-26) of follow-up. SETTING: Division of Gastroenterology and Endoscopic Unit, "Casa Sollievo della Sofferenza" Hospital. PATIENTS: One hundred thirty obesepatients with a mean (SD) weight of 118 (24) kg and mean (SD) body mass index (BMI) of 43 (8) kg/m(2). INTERVENTIONS: Positioning of BIB. MAIN OUTCOME MEASUREMENTS: Anthropometric and laboratory parameters. RESULTS: Overall, the mean (SD) weight and BMI decreased by 13.2 (8.2) kg and 5.1 (3.2) kg/m(2), respectively, compared with baseline. The mean glycemia, insulinemia, Homeostasis Model Assessment index, triglyceridemia, and alanine aminotransferase levels were significantly reduced. In the 91 responders (BMI decrease of > or = 3.5 kg/m(2)), the mean (SD) weight and BMI decreased by 16.4 (6.3) kg and 6.4 (2.3) kg/m(2), respectively, and severe liver steatosis decreased from 52% to 4% (P < .0001). On multivariate analysis, severe steatosis and the Homeostasis Model Assessment index were predictive of the response to BIB: odds ratios of 6.71 (95% CI, 2.23-20.19) and 3.18 (95% CI, 1.20-8.42). After a median follow-up of 22 months after BIB removal, 50% of responders maintained or continued to lose weight. LIMITATIONS: No sham-treated patients were included as comparative controls. CONCLUSIONS: Treatment was effective in inducing weight loss, improving liver steatosis, and restoring some components of the metabolic syndrome. 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Authors: Saurabh Chandan; Babu P Mohan; Shahab R Khan; Antonio Facciorusso; Daryl Ramai; Lena L Kassab; Neil Bhogal; Ravishankar Asokkumar; Gortrand Lopez-Nava; Stephanie McDonough; Douglas G Adler Journal: Obes Surg Date: 2021-01-06 Impact factor: 4.129
Authors: Ali M Al-Zubaidi; Hassan U Alghamdi; Abdu H Alzobydi; Irshad A Dhiloon; Laeeque A Qureshi Journal: World J Gastrointest Endosc Date: 2015-04-16
Authors: Violeta B Popov; Christopher C Thompson; Nitin Kumar; Maria M Ciarleglio; Yanhong Deng; Loren Laine Journal: Dig Dis Sci Date: 2016-05-20 Impact factor: 3.199
Authors: Ricardo José Fittipaldi-Fernandez; Idiberto José Zotarelli-Filho; Cristina Fajardo Diestel; Márcia Regina Simas Torres Klein; Marcelo Falcão de Santana; João Henrique Felicio de Lima; Fernando Santos Silva Bastos; Newton Teixeira Dos Santos Journal: Obes Surg Date: 2020-10-01 Impact factor: 4.129