Literature DB >> 21692648

Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson's disease.

Nilesh W Gaikwad1, Daniel Murman, Cheryl L Beseler, Muhammad Zahid, Eleanor G Rogan, Ercole L Cavalieri.   

Abstract

Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogen-DNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogen-DNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

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Year:  2011        PMID： 21692648      PMCID： PMC3142324          DOI： 10.3109/1354750X.2011.588725

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  45 in total

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Authors:  G Lévay; Q Ye; W J Bodell
Journal:  Exp Neurol       Date:  1997-08       Impact factor: 5.330

Review 2.  Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies.

Authors:  Caroline M Tanner
Journal:  Adv Neurol       Date:  2003

3.  Genetics of Parkinson's disease: LRRK2 on the rise.

Authors:  Alexis Brice
Journal:  Brain       Date:  2005-12       Impact factor: 13.501

4.  The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity.

Authors:  Muhammad Zahid; Ekta Kohli; Muhammad Saeed; Eleanor Rogan; Ercole Cavalieri
Journal:  Chem Res Toxicol       Date:  2006-01       Impact factor: 3.739

5.  An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2.

Authors:  S Harada; C Fujii; A Hayashi; N Ohkoshi
Journal:  Biochem Biophys Res Commun       Date:  2001-11-09       Impact factor: 3.575

6.  Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.

Authors:  Thomas S Hnasko; Nao Chuhma; Hui Zhang; Germaine Y Goh; David Sulzer; Richard D Palmiter; Stephen Rayport; Robert H Edwards
Journal:  Neuron       Date:  2010-03-11       Impact factor: 17.173

7.  Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione.

Authors:  K Cao; D E Stack; R Ramanathan; M L Gross; E G Rogan; E L Cavalieri
Journal:  Chem Res Toxicol       Date:  1998-08       Impact factor: 3.739

8.  Catecholestrogens in the brain: neuroendocrine integration.

Authors:  N Parvizi; F Ellendorff
Journal:  J Steroid Biochem       Date:  1983-07       Impact factor: 4.292

Review 9.  Cell systems and the toxic mechanism(s) of alpha-synuclein.

Authors:  Mark R Cookson; Marcel van der Brug
Journal:  Exp Neurol       Date:  2007-06-04       Impact factor: 5.330

10.  Urine biomarkers of risk in the molecular etiology of breast cancer.

Authors:  Nilesh W Gaikwad; Li Yang; Sandhya Pruthi; James N Ingle; Nicole Sandhu; Eleanor G Rogan; Ercole L Cavalieri
Journal:  Breast Cancer (Auckl)       Date:  2009-01-06
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  3 in total

1.  Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.

Authors:  Cailing Liu; Taiga Miyajima; Geetha Melangath; Takashi Miyai; Shivakumar Vasanth; Neha Deshpande; Varun Kumar; Stephan Ong Tone; Reena Gupta; Shan Zhu; Dijana Vojnovic; Yuming Chen; Eleanor G Rogan; Bodhiswatta Mondal; Muhammad Zahid; Ula V Jurkunas
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-18       Impact factor: 11.205

2.  2-Methoxyestradiol, an endogenous 17β-estradiol metabolite, inhibits microglial proliferation and activation via an estrogen receptor-independent mechanism.

Authors:  Sara A Schaufelberger; Marinella Rosselli; Federica Barchiesi; Delbert G Gillespie; Edwin K Jackson; Raghvendra K Dubey
Journal:  Am J Physiol Endocrinol Metab       Date:  2016-01-05       Impact factor: 4.310

3.  A cell-biased effect of estrogen in prion infection.

Authors:  Brendan Molloy; Hilary E M McMahon
Journal:  J Virol       Date:  2013-11-13       Impact factor: 5.103
  3 in total

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