Literature DB >> 19860648

Progress towards liver and lung-directed gene therapy with helper-dependent adenoviral vectors.

Nicola Brunetti-Pierri1, Philip Ng.   

Abstract

Helper-dependent adenoviral vectors (HDAd) have several characteristics making them very attractive for human gene therapy. These vectors are completely devoid of viral coding sequences and are able to mediate high efficiency transduction in vivo to direct high level transgene expression with negligible chronic toxicity. Progress towards liver and lung directed gene therapy with HDAd as well as the current obstacles facing human applications and possible strategies to overcome these obstacles are discussed.

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Year:  2009        PMID： 19860648     DOI： 10.2174/156652309789753310

Source DB:  PubMed          Journal:  Curr Gene Ther        ISSN： 1566-5232            Impact factor:   4.391


  16 in total

Review 1.  Helper-dependent adenoviral vectors for liver-directed gene therapy.

Authors:  Nicola Brunetti-Pierri; Philip Ng
Journal:  Hum Mol Genet       Date:  2011-04-05       Impact factor: 6.150

Review 2.  State-of-the-art gene-based therapies: the road ahead.

Authors:  Mark A Kay
Journal:  Nat Rev Genet       Date:  2011-04-06       Impact factor: 53.242

Review 3.  Engineering Stem Cells for Biomedical Applications.

Authors:  Perry T Yin; Edward Han; Ki-Bum Lee
Journal:  Adv Healthc Mater       Date:  2015-03-13       Impact factor: 9.933

4.  Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques.

Authors:  Nicola Brunetti-Pierri; Aimee Liou; Priti Patel; Donna Palmer; Nathan Grove; Milton Finegold; Pasquale Piccolo; Elizabeth Donnachie; Karen Rice; Arthur Beaudet; Charles Mullins; Philip Ng
Journal:  Mol Ther       Date:  2012-07-24       Impact factor: 11.454

5.  An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance.

Authors:  Vincenzo Cerullo; Iulia Diaconu; Valentina Romano; Mari Hirvinen; Matteo Ugolini; Sophie Escutenaire; Sirkka-Liisa Holm; Anja Kipar; Anna Kanerva; Akseli Hemminki
Journal:  Mol Ther       Date:  2012-07-24       Impact factor: 11.454

6.  Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

Authors:  Meritxell Morró; Joan Teichenne; Veronica Jimenez; Ramona Kratzer; Serena Marletta; Luca Maggioni; Cristina Mallol; Jesus Ruberte; Stefan Kochanek; Fatima Bosch; Eduard Ayuso
Journal:  Hum Gene Ther       Date:  2014-09       Impact factor: 5.695

Review 7.  Adenoviral vector immunity: its implications and circumvention strategies.

Authors:  Yadvinder S Ahi; Dinesh S Bangari; Suresh K Mittal
Journal:  Curr Gene Ther       Date:  2011-08       Impact factor: 4.391

8.  Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad.

Authors:  Francesco Vetrini; Nicola Brunetti-Pierri; Donna J Palmer; Terry Bertin; Nathan C Grove; Milton J Finegold; Philip Ng
Journal:  Mol Ther       Date:  2010-05-11       Impact factor: 11.454

Review 9.  Pulmonary gene delivery-Realities and possibilities.

Authors:  Uday K Baliga; David A Dean
Journal:  Exp Biol Med (Maywood)       Date:  2020-11-12

10.  Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.

Authors:  Nunzia Pastore; Keith Blomenkamp; Fabio Annunziata; Pasquale Piccolo; Pratibha Mithbaokar; Rosa Maria Sepe; Francesco Vetrini; Donna Palmer; Philip Ng; Elena Polishchuk; Simona Iacobacci; Roman Polishchuk; Jeffrey Teckman; Andrea Ballabio; Nicola Brunetti-Pierri
Journal:  EMBO Mol Med       Date:  2013-02-04       Impact factor: 12.137
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