OBJECTIVE: We sought to examine the role of microvesicular graft steatosis in relation to donor parameters. MATERIALS AND METHODS: We performed 269 consecutive orthotopic liver transplantations (OLT) between 2004 and 2006. Donor parameters of age, body mass index (BMI), intensive care unit (ICU) stay, hypotension, cardiac arrest, pressors, sodium concentration, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), bilirubin, and activated partial thromboplastin time (APTT), as well as the degree of microvesicular graft steatosis were collected into the study. The endpoint of the study was liver graft dysfunction (AST or ALT > 2500 IU/L or prothrombin index < 50% during the first 7 days after OLT). RESULTS: The risk of initial poor function (IPF) at day 7 posttransplantation was significantly related to hepatic microvesicular steatosis (odds ratio [OR] = 1.38 per 1 SD = 9.3%; P < .021). Accounting for the influence of the other donor factors produced little change in the numerical values of relative risk: from 1.22 (following exclusion of GGT) to 1.46 (after elimination of the influence of bilirubin concentration). A 50% increased risk of IPF was equivalent to 12% of the extent of steatosis. CONCLUSION: Microvesicular steatosis is a risk factor for early hepatic dysfunction after OLT.
OBJECTIVE: We sought to examine the role of microvesicular graft steatosis in relation to donor parameters. MATERIALS AND METHODS: We performed 269 consecutive orthotopic liver transplantations (OLT) between 2004 and 2006. Donor parameters of age, body mass index (BMI), intensive care unit (ICU) stay, hypotension, cardiac arrest, pressors, sodium concentration, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), bilirubin, and activated partial thromboplastin time (APTT), as well as the degree of microvesicular graft steatosis were collected into the study. The endpoint of the study was liver graft dysfunction (AST or ALT > 2500 IU/L or prothrombin index < 50% during the first 7 days after OLT). RESULTS: The risk of initial poor function (IPF) at day 7 posttransplantation was significantly related to hepatic microvesicular steatosis (odds ratio [OR] = 1.38 per 1 SD = 9.3%; P < .021). Accounting for the influence of the other donor factors produced little change in the numerical values of relative risk: from 1.22 (following exclusion of GGT) to 1.46 (after elimination of the influence of bilirubin concentration). A 50% increased risk of IPF was equivalent to 12% of the extent of steatosis. CONCLUSION:Microvesicular steatosis is a risk factor for early hepatic dysfunction after OLT.
Authors: Kim H H Liss; Kyle S McCommis; Kari T Chambers; Terri A Pietka; George G Schweitzer; Sara L Park; Ilke Nalbantoglu; Carla J Weinheimer; Angela M Hall; Brian N Finck Journal: Liver Transpl Date: 2018-07 Impact factor: 5.799
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Authors: Henning Reis; Patricia T Peterek; Jeremias Wohlschlaeger; Gernot M Kaiser; Zoltan Mathe; Benjamin Juntermanns; Georgios C Sotiropoulos; Ulrich Beckhove; Ali Canbay; Ulrike Wirges; Andre Scherag; Juergen-Walter Treckmann; Andreas Paul; Hideo Andreas Baba Journal: Virchows Arch Date: 2013-12-03 Impact factor: 4.064
Authors: Rohan C Siriwardana; See Ching Chan; Kenneth S H Chok; Chung Mau Lo; Sheung Tat Fan Journal: HPB (Oxford) Date: 2012-05-29 Impact factor: 3.647
Authors: Natalie M Bath; Glen Leverson; David P Al-Adra; Anthony M D'Alessandro; Joshua D Mezrich; David P Foley Journal: Liver Transpl Date: 2020-09 Impact factor: 5.799