PURPOSE: To optimize the contrast agent dose and delivery rate used in a novel whole-body magnetic resonance angiography (MRA) protocol using a 3.0T MR scanner. MATERIALS AND METHODS: Six groups of 20 consenting volunteers underwent whole-body MRA, with each group receiving a different contrast dose and contrast delivery rate. The arterial tree was divided into 16 segments and the image quality at each of the anatomical locations, covering the whole body, was assessed. Qualitative analysis was carried out using a scoring assessment of image quality, and quantitative assessments were performed by measuring contrast-to-noise (CNR) and a signal-to-noise (SNR) index. RESULTS: Reducing the contrast dose from 40 mL to 25 mL was found to significantly increase the CNR in several vessels of interest in the arterial tree. There was also a significant increase in the qualitative image quality score (P < 0.001). CONCLUSION: This study demonstrates that reducing the contrast dose at 3.0T can result in an increase in the CNR in the vessels of interest without significantly affecting the SNR.
PURPOSE: To optimize the contrast agent dose and delivery rate used in a novel whole-body magnetic resonance angiography (MRA) protocol using a 3.0T MR scanner. MATERIALS AND METHODS: Six groups of 20 consenting volunteers underwent whole-body MRA, with each group receiving a different contrast dose and contrast delivery rate. The arterial tree was divided into 16 segments and the image quality at each of the anatomical locations, covering the whole body, was assessed. Qualitative analysis was carried out using a scoring assessment of image quality, and quantitative assessments were performed by measuring contrast-to-noise (CNR) and a signal-to-noise (SNR) index. RESULTS: Reducing the contrast dose from 40 mL to 25 mL was found to significantly increase the CNR in several vessels of interest in the arterial tree. There was also a significant increase in the qualitative image quality score (P < 0.001). CONCLUSION: This study demonstrates that reducing the contrast dose at 3.0T can result in an increase in the CNR in the vessels of interest without significantly affecting the SNR.
Authors: Judith Enders; Elke Zimmermann; Matthias Rief; Peter Martus; Randolf Klingebiel; Patrick Asbach; Christian Klessen; Gerd Diederichs; Thomas Bengner; Ulf Teichgräber; Bernd Hamm; Marc Dewey Journal: BMC Med Imaging Date: 2011-02-10 Impact factor: 1.930
Authors: Judith Enders; Matthias Rief; Elke Zimmermann; Patrick Asbach; Gerd Diederichs; Christoph Wetz; Eberhard Siebert; Moritz Wagner; Bernd Hamm; Marc Dewey Journal: PLoS One Date: 2013-12-31 Impact factor: 3.240
Authors: Jonathan R Weir-McCall; Suzanne L Duce; Stephen J Gandy; Shona Z Matthew; Patricia Martin; Deirdre B Cassidy; Lynne McCormick; Jill J F Belch; Allan D Struthers; Helen M Colhoun; J Graeme Houston Journal: BMC Med Imaging Date: 2016-02-29 Impact factor: 1.930
Authors: S J Gandy; M Lambert; J J F Belch; I D Cavin; E Crowe; R Littleford; J A Macfarlane; S Z Matthew; P Martin; R S Nicholas; A D Struthers; F Sullivan; S A Waugh; R D White; J R Weir-McCall; J G Houston Journal: Clin Radiol Date: 2015-03-16 Impact factor: 2.350
Authors: Jonathan R Weir-McCall; Deirdre B Cassidy; Jill J F Belch; Stephen J Gandy; J G Houston; Matthew A Lambert; Roberta C Littleford; Janice Rowland; Allan D Struthers; Faisel Khan Journal: Br J Radiol Date: 2016-06-28 Impact factor: 3.039
Authors: Matthew A Lambert; Jonathan R Weir-McCall; Marco Salsano; Stephen J Gandy; Daniel Levin; Ian Cavin; Roberta Littleford; Jennifer A MacFarlane; Shona Z Matthew; Richard S Nicholas; Allan D Struthers; Frank Sullivan; Shelley A Henderson; Richard D White; Jill J F Belch; J Graeme Houston Journal: Radiology Date: 2018-05-01 Impact factor: 29.146
Authors: Suzanne L Duce; Jonathan R Weir-McCall; Stephen J Gandy; Shona Z Matthew; Deirdre B Cassidy; Lynne McCormick; Petra Rauchhaus; Helen Looker; Helen M Colhoun; J Graeme Houston Journal: Cardiovasc Diabetol Date: 2015-09-18 Impact factor: 9.951
Authors: Jonathan R Weir-McCall; Faisel Khan; Matthew A Lambert; Carly L Adamson; Michael Gardner; Stephen J Gandy; Prasad Guntur Ramkumar; Jill J F Belch; Allan D Struthers; Petra Rauchhaus; Andrew D Morris; J Graeme Houston Journal: PLoS One Date: 2014-06-16 Impact factor: 3.240
Authors: Jonathan R Weir-McCall; Richard D White; Prasad G Ramkumar; Stephen J Gandy; Faisel Khan; Jill J F Belch; Allan D Struthers; J Graeme Houston Journal: Int J Cardiovasc Imaging Date: 2016-01-25 Impact factor: 2.357