BACKGROUND: Citrus fruit has shown a favorable effect against various cancers. To better understand their role in cancer risk, we analyzed data from a series of case-control studies conducted in Italy and Switzerland. PATIENTS AND METHODS: The studies included 955 patients with oral and pharyngeal cancer, 395 with esophageal, 999 with stomach, 3,634 with large bowel, 527 with laryngeal, 2,900 with breast, 454 with endometrial, 1,031 with ovarian, 1,294 with prostate, and 767 with renal cell cancer. All cancers were incident and histologically confirmed. Controls were admitted to the same network of hospitals for acute, nonneoplastic conditions. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for major identified confounding factors for each cancer site, and energy intake. RESULTS: The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer. No consistent association was found with breast, endometrial, ovarian, prostate, and renal cell cancer. CONCLUSIONS: Our findings indicate that citrus fruit has a protective role against cancers of the digestive and upper respiratory tract.
BACKGROUND: Citrus fruit has shown a favorable effect against various cancers. To better understand their role in cancer risk, we analyzed data from a series of case-control studies conducted in Italy and Switzerland. PATIENTS AND METHODS: The studies included 955 patients with oral and pharyngeal cancer, 395 with esophageal, 999 with stomach, 3,634 with large bowel, 527 with laryngeal, 2,900 with breast, 454 with endometrial, 1,031 with ovarian, 1,294 with prostate, and 767 with renal cell cancer. All cancers were incident and histologically confirmed. Controls were admitted to the same network of hospitals for acute, nonneoplastic conditions. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for major identified confounding factors for each cancer site, and energy intake. RESULTS: The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer. No consistent association was found with breast, endometrial, ovarian, prostate, and renal cell cancer. CONCLUSIONS: Our findings indicate that citrus fruit has a protective role against cancers of the digestive and upper respiratory tract.
Authors: Lauren A Wise; Rose G Radin; Julie R Palmer; Shiriki K Kumanyika; Deborah A Boggs; Lynn Rosenberg Journal: Am J Clin Nutr Date: 2011-11-09 Impact factor: 7.045
Authors: Shu-Chun Chuang; Mazda Jenab; Julia E Heck; Cristina Bosetti; Renato Talamini; Keitaro Matsuo; Xavier Castellsague; Silvia Franceschi; Rolando Herrero; Deborah M Winn; Carlo La Vecchia; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Luigino Dal Maso; Karl Kelsey; Michael D McClean; Thomas Vaughan; Philip Lazarus; Joshua Muscat; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Jose Eluf-Neto; Richard B Hayes; Mark Purdue; Stefania Boccia; Gabriella Cadoni; David Zaridze; Sergio Koifman; Maria Paula Curado; Wolfgang Ahrens; Simone Benhamou; Elena Matos; Pagona Lagiou; Neonilla Szeszenia-Dabrowska; Andrew F Olshan; Leticia Fernandez; Ana Menezes; Antonio Agudo; Alexander W Daudt; Franco Merletti; Gary J Macfarlane; Kristina Kjaerheim; Dana Mates; Ivana Holcatova; Stimson Schantz; Guo-Pei Yu; Lorenzo Simonato; Hermann Brenner; Heiko Mueller; David I Conway; Peter Thomson; Eleonora Fabianova; Ariana Znaor; Peter Rudnai; Claire M Healy; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Cancer Causes Control Date: 2011-10-29 Impact factor: 2.506
Authors: Daniel S Peiffer; Noah P Zimmerman; Li-Shu Wang; Benjamin W S Ransom; Steven G Carmella; Chieh-Ti Kuo; Jibran Siddiqui; Jo-Hsin Chen; Kiyoko Oshima; Yi-Wen Huang; Stephen S Hecht; Gary D Stoner Journal: Cancer Prev Res (Phila) Date: 2014-03-25