Linda F Brown1, Kurt Kroenke. 1. Psychology Department, Indiana University Purdue University, Indianapolis, IN 46202, USA. lfbrown@iupui.edu
Abstract
BACKGROUND: Fatigue is an important symptom in cancer and has been shown to be associated with psychological distress. OBJECTIVE: This review assesses evidence regarding associations of cancer-related fatigue with depression and anxiety. METHOD: Database searches yielded 59 studies reporting correlation coefficients or odds ratios. RESULTS: The combined sample size was 12,103. Almost all studies showed a correlation of fatigue with depression and with anxiety. However, 31 different instruments were used to assess fatigue, suggesting a lack of consensus on measurement. CONCLUSION: This review confirms the association of fatigue with depression and anxiety. Directionality needs to be better delineated in longitudinal studies.
BACKGROUND:Fatigue is an important symptom in cancer and has been shown to be associated with psychological distress. OBJECTIVE: This review assesses evidence regarding associations of cancer-related fatigue with depression and anxiety. METHOD: Database searches yielded 59 studies reporting correlation coefficients or odds ratios. RESULTS: The combined sample size was 12,103. Almost all studies showed a correlation of fatigue with depression and with anxiety. However, 31 different instruments were used to assess fatigue, suggesting a lack of consensus on measurement. CONCLUSION: This review confirms the association of fatigue with depression and anxiety. Directionality needs to be better delineated in longitudinal studies.
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