| Literature DB >> 19854648 |
Mark D Rosen1, Craig R Woods, Steven D Goldberg, Michael D Hack, A Dawn Bounds, Young Yang, Pamela C Wagaman, Victor K Phuong, Angela P Ameriks, Terrance D Barrett, Kimon C Kanelakis, Jui Chang Chuang, Jui Chang, Nigel P Shankley, Michael H Rabinowitz.
Abstract
A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. The synthesis, structure-activity relationship profile, and in-vitro pharmacological characterization of this inaugural series of HRI kinase inhibitors are detailed.Entities:
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Year: 2009 PMID： 19854648 DOI： 10.1016/j.bmcl.2009.10.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823