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Literature DB >> 19854504

A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems.

Tae-il Kim¹, Minhyung Lee, Sung Wan Kim.

Abstract

Guanidinylated bioreducible polymer (GBP) was developed for gene delivery systems utilizing cellular penetrating ability of guanidine groups. GBP could retard pDNA from a weight ratio of 5 completely in agarose gel electrophoresis but pDNA was released from GBP polyplexes even at a weight ratio of 20 in reducing condition (2.5mm DTT) due to their biodegradation. GBP also could construct 200 nm-sized and positively charged (approximately 30 mV) polyplex nanoparticles with pDNA. The cytotoxicity of GBP was found to be minimal and GBP showed about 8 folds improved transfection efficiency than a scaffold polymer, poly(cystaminebisacrylamide-diaminohexane) (poly(CBA-DAH)) and even higher transfection efficiency than PEI25k in mammalian cell lines. Its high cellular uptake efficiency (96.1%) and strong nuclear localization ability for pDNA delivery due to the structural advantage of bioreducible polymer and guanidine groups were also identified, suggesting GBP is a promising candidate for efficient gene delivery systems. (c) 2009 Elsevier Ltd. All rights reserved.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19854504 PMCID： PMC2813999 DOI： 10.1016/j.biomaterials.2009.10.034

Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479

34 in total

Review 1. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer.

Authors: Thomas Merdan; Jindrich Kopecek; Thomas Kissel
Journal: Adv Drug Deliv Rev Date: 2002-09-13 Impact factor: 15.470

Review 2. Intracellular cargo delivery using tat peptide and derivatives.

Authors: Ming Zhao; Ralph Weissleder
Journal: Med Res Rev Date: 2004-01 Impact factor: 12.944

3. Cross-linked microparticles as carriers for the delivery of plasmid DNA for vaccine development.

Authors: Sarah L Goh; Niren Murthy; Mingcheng Xu; Jean M J Fréchet
Journal: Bioconjug Chem Date: 2004 May-Jun Impact factor: 4.774

4. Novel bioreducible poly(amido amine)s for highly efficient gene delivery.

Authors: Chao Lin; Zhiyuan Zhong; Martin C Lok; Xulin Jiang; Wim E Hennink; Jan Feijen; Johan F J Engbersen
Journal: Bioconjug Chem Date: 2007 Jan-Feb Impact factor: 4.774

Review 5. The design of guanidinium-rich transporters and their internalization mechanisms.

Authors: Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal: Adv Drug Deliv Rev Date: 2007-11-09 Impact factor: 15.470

6. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine.

Authors: M A Gosselin; W Guo; R J Lee
Journal: Bioconjug Chem Date: 2001 Nov-Dec Impact factor: 4.774

7. Synthesis of biodegradable cross-linked poly(beta-amino ester) for gene delivery and its modification, inducing enhanced transfection efficiency and stepwise degradation.

Authors: Tae-Il Kim; Hyo Jung Seo; Joon Sig Choi; Jae Keun Yoon; Jung-Un Baek; Kwan Kim; Jong-Sang Park
Journal: Bioconjug Chem Date: 2005 Sep-Oct Impact factor: 4.774

Review 8. Biodegradable polymers as non-viral carriers for plasmid DNA delivery.

Authors: Jordy Luten; Cornelus F van Nostrum; Stefaan C De Smedt; Wim E Hennink
Journal: J Control Release Date: 2007-12-04 Impact factor: 9.776

9. Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems.

Authors: Tae-il Kim; Mei Ou; Minhyung Lee; Sung Wan Kim
Journal: Biomaterials Date: 2008-11-12 Impact factor: 12.479

10. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.

Authors: Kanjiro Miyata; Yoshinori Kakizawa; Nobuhiro Nishiyama; Atsushi Harada; Yuichi Yamasaki; Hiroyuki Koyama; Kazunori Kataoka
Journal: J Am Chem Soc Date: 2004-03-03 Impact factor: 15.419

23 in total

1. Bioreducible polymers for gene delivery.

Authors: Tae-Il Kim; Sung Wan Kim
Journal: React Funct Polym Date: 2011-03-01 Impact factor: 3.975

2. Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer.

Authors: Tae-Il Kim; Minhyung Lee; Sung Wan Kim
Journal: J Control Release Date: 2011-09-16 Impact factor: 9.776

10. Supramolecular Hydrogels Based on Nanoclay and Guanidine-Rich Chitosan: Injectable and Moldable Osteoinductive Carriers.

Authors: Xiao Zhang; Jiabing Fan; Chung-Sung Lee; Soyon Kim; Chen Chen; Min Lee
Journal: ACS Appl Mater Interfaces Date: 2020-03-24 Impact factor: 9.229

A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems.

Review 1. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer.

Review 2. Intracellular cargo delivery using tat peptide and derivatives.

3. Cross-linked microparticles as carriers for the delivery of plasmid DNA for vaccine development.

4. Novel bioreducible poly(amido amine)s for highly efficient gene delivery.

Review 5. The design of guanidinium-rich transporters and their internalization mechanisms.

6. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine.

7. Synthesis of biodegradable cross-linked poly(beta-amino ester) for gene delivery and its modification, inducing enhanced transfection efficiency and stepwise degradation.

Review 8. Biodegradable polymers as non-viral carriers for plasmid DNA delivery.

9. Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems.

10. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.

1. Bioreducible polymers for gene delivery.

2. Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer.

3. Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems.

Review 4. Bioreducible polycations in nucleic acid delivery: past, present, and future trends.

Review 5. Development of protein mimics for intracellular delivery.

6. Multiplexed supramolecular self-assembly for non-viral gene delivery.

Review 7. Polymers in small-interfering RNA delivery.

Review 8. Bioreducible polymers for therapeutic gene delivery.

9. Bioreducible polypeptide containing cell-penetrating sequence for efficient gene delivery.

10. Supramolecular Hydrogels Based on Nanoclay and Guanidine-Rich Chitosan: Injectable and Moldable Osteoinductive Carriers.