| Literature DB >> 19852440 |
Patrizia Ciminiello1, Carmela Dell'aversano, Emma Dello Iacovo, Ernesto Fattorusso, Martino Forino, Laura Grauso, Luciana Tartaglione, Chiara Florio, Paola Lorenzon, Marco De Bortoli, Aurelia Tubaro, Mark Poli, Gary Bignami.
Abstract
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.Entities:
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Year: 2009 PMID： 19852440 DOI： 10.1021/tx900259v
Source DB: PubMed Journal: Chem Res Toxicol ISSN： 0893-228X Impact factor: 3.739