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Literature DB >> 19851886

CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA.

Liping Yang¹, Ning Liu, Xiang Hu, Wenfeng Zhang, Tao Wang, Hong Li, Bo Zhang, Shuanglin Xiang, Jianlin Zhou, Jian Zhang.

Abstract

TNFAIP1 is a protein which can be induced by tumor necrosis factoralpha (TNFalpha) and interleukin-6 (IL-6), it may play roles in DNA synthesis, DNA repair, cell apoptosis and human diseases. However, very little has been known about how TNFAIP1 acts in these physiological processes. In this paper, CK2beta was identified as a partner of TNFAIP1 by screening the HeLa cDNA library in yeast two-hybrid system with TNFAIP1 as a bait. Furthermore, it was demonstrated that CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. It is suggested that the phosphorylation of TNFAIP1 may be required for its functions.

Entities: Gene Species

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Year: 2009 PMID： 19851886 DOI： 10.1007/s11033-009-9863-1

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

21 in total

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Journal: Biochim Biophys Acta Date: 2005-07-10

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Journal: Mol Biol Rep Date: 2009-07-11 Impact factor: 2.316

12 in total

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2. MYBBP1A: a new Ipr1's binding protein in mice.

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3. IL-6/STAT3/TFF3 signaling regulates human biliary epithelial cell migration and wound healing in vitro.

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Journal: Mol Biol Rep Date: 2012-07-19 Impact factor: 2.742