AIM: To compare the gene expression profile in a pair of HBV-infected twins. METHODS: The gene expression profile was compared in a pair of HBV-infected twins. RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or down-regulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-alphaIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-alphaIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-alphaIP1 that shares a significant homology with some human, mouse, and C elegan proteins. CONCLUSION: TNF-alphaIP1 may play a role in the innate immunity against HBV.
AIM: To compare the gene expression profile in a pair of HBV-infected twins. METHODS: The gene expression profile was compared in a pair of HBV-infected twins. RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or down-regulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-alphaIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-alphaIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-alphaIP1 that shares a significant homology with some human, mouse, and C elegan proteins. CONCLUSION:TNF-alphaIP1 may play a role in the innate immunity against HBV.
Authors: L Luo; R C Salunga; H Guo; A Bittner; K C Joy; J E Galindo; H Xiao; K E Rogers; J S Wan; M R Jackson; M G Erlander Journal: Nat Med Date: 1999-01 Impact factor: 53.440
Authors: T Welte; D Leitenberg; B N Dittel; B K al-Ramadi; B Xie; Y E Chin; C A Janeway; A L Bothwell; K Bottomly; X Y Fu Journal: Science Date: 1999-01-08 Impact factor: 47.728
Authors: Rebecca M Green; Fabienne Gally; Jonathon G Keeney; Scott Alper; Bifeng Gao; Min Han; Richard J Martin; Andrew R Weinberger; Stephanie R Case; Maisha N Minor; Hong Wei Chu Journal: PLoS One Date: 2009-08-31 Impact factor: 3.240