BACKGROUND: Acanthamoeba sp. are known to cause fatal granulomatous Acanthamoeba encephalitis (GAE) in immunocompromised patients. METHODS: The case of a 17 year old immunocompetent patient with acute purulent meningoencephalitis is reported. RESULTS: After substantial improvement of cerebrospinal fluid under conventional antimicrobial treatment the patient was suffering several relapses. The causative agent was identified as Acanthamoeba lenticulata T5 which entered the CNS through a bone dehiscence of ethmoidal cells. Due to severe vasospasm the patient developed multiple strokes, which led to marked neurologic sequels. CONCLUSIONS: This case report demonstrates successful treatment of usually lethal GAE in an immunocompetent patient with high dose meropenem, linezolid, moxifloxacin and fluconazole followed by a partially adapted antimicrobial combination therapy.
BACKGROUND:Acanthamoeba sp. are known to cause fatal granulomatous Acanthamoeba encephalitis (GAE) in immunocompromised patients. METHODS: The case of a 17 year old immunocompetent patient with acute purulent meningoencephalitis is reported. RESULTS: After substantial improvement of cerebrospinal fluid under conventional antimicrobial treatment the patient was suffering several relapses. The causative agent was identified as Acanthamoeba lenticulata T5 which entered the CNS through a bone dehiscence of ethmoidal cells. Due to severe vasospasm the patient developed multiple strokes, which led to marked neurologic sequels. CONCLUSIONS: This case report demonstrates successful treatment of usually lethal GAE in an immunocompetent patient with high dose meropenem, linezolid, moxifloxacin and fluconazole followed by a partially adapted antimicrobial combination therapy.
Authors: T Singhal; A Bajpai; V Kalra; S K Kabra; J C Samantaray; G Satpathy; A K Gupta Journal: Pediatr Infect Dis J Date: 2001-06 Impact factor: 2.129
Authors: Franz Petry; Michael Torzewski; Jürgen Bohl; Thomas Wilhelm-Schwenkmezger; Patrick Scheid; Julia Walochnik; Rolf Michel; Lothar Zöller; Konrad J Werhahn; Sucharit Bhakdi; Karl J Lackner Journal: J Clin Microbiol Date: 2006-05 Impact factor: 5.948
Authors: Jacob Lorenzo-Morales; Carmen M Martín-Navarro; Atteneri López-Arencibia; María A Santana-Morales; Raquel N Afonso-Lehmann; Sutherland K Maciver; Basilio Valladares; Enrique Martínez-Carretero Journal: Antimicrob Agents Chemother Date: 2010-09-20 Impact factor: 5.191
Authors: C M Martín-Navarro; A López-Arencibia; F Arnalich-Montiel; B Valladares; J E Piñero; J Lorenzo-Morales Journal: Graefes Arch Clin Exp Ophthalmol Date: 2013-05-19 Impact factor: 3.117