Literature DB >> 19846340

Opioid-receptor-heteromer-specific trafficking and pharmacology.

Richard M van Rijn1, Jennifer L Whistler, Maria Waldhoer.   

Abstract

Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19846340      PMCID： PMC2900797          DOI： 10.1016/j.coph.2009.09.007

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  66 in total

1.  Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption.

Authors:  Elyssa B Margolis; Howard L Fields; Gregory O Hjelmstad; Jennifer M Mitchell
Journal:  J Neurosci       Date:  2008-11-26       Impact factor: 6.167

2.  The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?

Authors:  Richard M van Rijn; Jennifer L Whistler
Journal:  Mol Interv       Date:  2008-12

3.  Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

Authors:  Fabien M Décaillot; Raphael Rozenfeld; Achla Gupta; Lakshmi A Devi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-03       Impact factor: 11.205

4.  Construction of covalently coupled, concatameric dimers of 7TM receptors.

Authors:  Marie Terpager; D Jason Scholl; Valentina Kubale; Lene Martini; Christian E Elling; Thue W Schwartz
Journal:  J Recept Signal Transduct Res       Date:  2009       Impact factor: 2.092

5.  Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist.

Authors:  P Chu; S Murray; D Lissin; M von Zastrow
Journal:  J Biol Chem       Date:  1997-10-24       Impact factor: 5.157

6.  The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake.

Authors:  Richard M van Rijn; Jennifer L Whistler
Journal:  Biol Psychiatry       Date:  2009-07-03       Impact factor: 13.382

7.  Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivation.

Authors:  Juan F Lopez-Gimenez; M Teresa Vilaró; Graeme Milligan
Journal:  Mol Pharmacol       Date:  2008-08-14       Impact factor: 4.436

8.  Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

Authors:  Adam J Kuszak; Sethuramasundaram Pitchiaya; Jessica P Anand; Henry I Mosberg; Nils G Walter; Roger K Sunahara
Journal:  J Biol Chem       Date:  2009-06-19       Impact factor: 5.157

9.  Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.

Authors:  Grégory Scherrer; Noritaka Imamachi; Yu-Qing Cao; Candice Contet; Françoise Mennicken; Dajan O'Donnell; Brigitte L Kieffer; Allan I Basbaum
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

10.  Building a new conceptual framework for receptor heteromers.

Authors:  Sergi Ferré; Ruben Baler; Michel Bouvier; Marc G Caron; Lakshmi A Devi; Thierry Durroux; Kjell Fuxe; Susan R George; Jonathan A Javitch; Martin J Lohse; Ken Mackie; Graeme Milligan; Kevin D G Pfleger; Jean-Philippe Pin; Nora D Volkow; Maria Waldhoer; Amina S Woods; Rafael Franco
Journal:  Nat Chem Biol       Date:  2009-03       Impact factor: 15.040
View more
  42 in total

Review 1.  Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches.

Authors:  Claire Gavériaux-Ruff; Brigitte Lina Kieffer
Journal:  Behav Pharmacol       Date:  2011-09       Impact factor: 2.293

2.  Structural biology: How opioid drugs bind to receptors.

Authors:  Marta Filizola; Lakshmi A Devi
Journal:  Nature       Date:  2012-05-16       Impact factor: 49.962

3.  Peripheral δ-opioid receptors attenuate the exercise pressor reflex.

Authors:  Anna K Leal; Katsuya Yamauchi; Joyce Kim; Victor Ruiz-Velasco; Marc P Kaufman
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-09       Impact factor: 4.733

4.  The oligomeric state sets GABA(B) receptor signalling efficacy.

Authors:  Laëtitia Comps-Agrar; Julie Kniazeff; Lenea Nørskov-Lauritsen; Damien Maurel; Martin Gassmann; Nathalie Gregor; Laurent Prézeau; Bernhard Bettler; Thierry Durroux; Eric Trinquet; Jean-Philippe Pin
Journal:  EMBO J       Date:  2011-05-06       Impact factor: 11.598

5.  Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.

Authors:  Richard J Ward; John D Pediani; Graeme Milligan
Journal:  J Biol Chem       Date:  2011-09-09       Impact factor: 5.157

6.  GPCR dimers fall apart.

Authors:  Nevin A Lambert
Journal:  Sci Signal       Date:  2010-03-30       Impact factor: 8.192

7.  The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

Authors:  Matthew D Metcalf; Ajay S Yekkirala; Michael D Powers; Kelley F Kitto; Carolyn A Fairbanks; George L Wilcox; Philip S Portoghese
Journal:  ACS Chem Neurosci       Date:  2012-05-22       Impact factor: 4.418

8.  Oligomerization of G-protein-coupled receptors: a reality.

Authors:  Sergi Ferré; Rafael Franco
Journal:  Curr Opin Pharmacol       Date:  2009-12-16       Impact factor: 5.547

9.  A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists.

Authors:  Yue Wang; Ming Yan; Guang-Yao Zheng; Ling He; Huan Yang
Journal:  Acta Pharmacol Sin       Date:  2014-06-16       Impact factor: 6.150

10.  Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.

Authors:  Malliga R Iyer; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Journal:  Bioorg Med Chem       Date:  2013-04-03       Impact factor: 3.641
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.