Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.

× No keyword cloud information.

39 in total

Review 1. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors: K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal: Chem Soc Rev Date: 2012-06-28 Impact factor: 54.564

2. Transcriptional kinases: Less is more (or less).

Authors: Thomas G Boyer
Journal: Nat Chem Biol Date: 2016-01 Impact factor: 15.040

3. A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery.

Authors: Timothy Cholko; Wei Chen; Zhiye Tang; Chia-En A Chang
Journal: J Comput Aided Mol Des Date: 2018-05-08 Impact factor: 3.686

4. Discovery of CDK8/CycC Ligands with a New Virtual Screening Tool.

Authors: Wei Chen; Xiaodong Ren; Chia-En A Chang
Journal: ChemMedChem Date: 2018-12-10 Impact factor: 3.466

5. Design, synthesis, and biological evaluation of a biyouyanagin compound library.

Authors: K C Nicolaou; Silvano Sanchini; David Sarlah; Gang Lu; T Robert Wu; Daniel K Nomura; Benjamin F Cravatt; Beatrice Cubitt; Juan C de la Torre; Ann J Hessell; Dennis R Burton
Journal: Proc Natl Acad Sci U S A Date: 2011-01-18 Impact factor: 11.205

Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.

Review 1. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

2. Transcriptional kinases: Less is more (or less).

3. A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery.

4. Discovery of CDK8/CycC Ligands with a New Virtual Screening Tool.

5. Design, synthesis, and biological evaluation of a biyouyanagin compound library.

6. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.

7. Formal total synthesis of (±)-cortistatin A.

8. Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling.

9. Synthesis of cortistatins A, J, K and L.

10. CDK8 Kinase Activity Promotes Glycolysis.