BACKGROUND/AIMS: The aim of this study was to assess the combined effects of exercise and dietary glycemic load on insulin resistance in older obese adults. METHODS: Eleven men and women (62 +/- 2 years; 97.6 +/- 4.8 kg; body mass index 33.2 +/- 2.0) participated in a 12-week supervised exercise program, 5 days/week, for about 1 h/day, at 80-85% of maximum heart rate. Dietary glycemic load was calculated from dietary intake records. Insulin resistance was determined using the euglycemic (5.0 mM) hyperinsulinemic (40 mU/m(2)/min) clamp. RESULTS: The intervention improved insulin sensitivity (2.37 +/- 0.37 to 3.28 +/- 0.52 mg/kg/min, p < 0.004), increased VO(2max) (p < 0.009), and decreased body weight (p < 0.009). Despite similar caloric intakes (1,816 +/- 128 vs. 1,610 +/- 100 kcal/day), dietary glycemic load trended towards a decrease during the study (140 +/- 10 g before, vs. 115 +/- 8 g during, p < 0.04). The change in insulin sensitivity correlated with the change in glycemic load (r = 0.84, p < 0.009). Four subjects reduced their glycemic load by 61 +/- 8%, and had significantly greater increases in insulin sensitivity (78 +/- 11 vs. 23 +/- 8%, p < 0.003), and decreases in body weight (p < 0.004) and plasma triglycerides (p < 0.04) compared to the rest of the group. CONCLUSION: The data suggest that combining a low-glycemic diet with exercise may provide an alternative and more effective treatment for insulin resistance in older obese adults. Copyright (c) 2009 S. Karger AG, Basel.
BACKGROUND/AIMS: The aim of this study was to assess the combined effects of exercise and dietary glycemic load on insulin resistance in older obese adults. METHODS: Eleven men and women (62 +/- 2 years; 97.6 +/- 4.8 kg; body mass index 33.2 +/- 2.0) participated in a 12-week supervised exercise program, 5 days/week, for about 1 h/day, at 80-85% of maximum heart rate. Dietary glycemic load was calculated from dietary intake records. Insulin resistance was determined using the euglycemic (5.0 mM) hyperinsulinemic (40 mU/m(2)/min) clamp. RESULTS: The intervention improved insulin sensitivity (2.37 +/- 0.37 to 3.28 +/- 0.52 mg/kg/min, p < 0.004), increased VO(2max) (p < 0.009), and decreased body weight (p < 0.009). Despite similar caloric intakes (1,816 +/- 128 vs. 1,610 +/- 100 kcal/day), dietary glycemic load trended towards a decrease during the study (140 +/- 10 g before, vs. 115 +/- 8 g during, p < 0.04). The change in insulin sensitivity correlated with the change in glycemic load (r = 0.84, p < 0.009). Four subjects reduced their glycemic load by 61 +/- 8%, and had significantly greater increases in insulin sensitivity (78 +/- 11 vs. 23 +/- 8%, p < 0.003), and decreases in body weight (p < 0.004) and plasma triglycerides (p < 0.04) compared to the rest of the group. CONCLUSION: The data suggest that combining a low-glycemic diet with exercise may provide an alternative and more effective treatment for insulin resistance in older obese adults. Copyright (c) 2009 S. Karger AG, Basel.
Authors: Margarita Teran-Garcia; Tuomo Rankinen; Robert A Koza; D C Rao; Claude Bouchard Journal: Am J Physiol Endocrinol Metab Date: 2005-02-01 Impact factor: 4.310
Authors: Valerie B O'Leary; Christine M Marchetti; Raj K Krishnan; Bradley P Stetzer; Frank Gonzalez; John P Kirwan Journal: J Appl Physiol (1985) Date: 2005-12-22
Authors: Robert H Coker; Nicholas P Hays; Rick H Williams; Amy D Brown; Scott A Freeling; Patrick M Kortebein; Dennis H Sullivan; Raymond D Starling; William J Evans Journal: Med Sci Sports Exerc Date: 2006-03 Impact factor: 5.411
Authors: M I Harris; K M Flegal; C C Cowie; M S Eberhardt; D E Goldstein; R R Little; H M Wiedmeyer; D D Byrd-Holt Journal: Diabetes Care Date: 1998-04 Impact factor: 19.112
Authors: Karen R Kelly; Sankar D Navaneethan; Thomas P J Solomon; Jacob M Haus; Marc Cook; Hope Barkoukis; John P Kirwan Journal: Med Sci Sports Exerc Date: 2014 Impact factor: 5.411
Authors: Thomas Pj Solomon; Jacob M Haus; Karen R Kelly; Marc D Cook; Julianne Filion; Michael Rocco; Sangeeta R Kashyap; Richard M Watanabe; Hope Barkoukis; John P Kirwan Journal: Am J Clin Nutr Date: 2010-10-27 Impact factor: 7.045
Authors: Karen R Kelly; Jacob M Haus; Thomas P J Solomon; Aimee J Patrick-Melin; Marc Cook; Michael Rocco; Hope Barkoukis; John P Kirwan Journal: J Nutr Date: 2011-04-27 Impact factor: 4.798
Authors: Steven K Malin; Nicole Niemi; Thomas P J Solomon; Jacob M Haus; Karen R Kelly; Julianne Filion; Michael Rocco; Sangeeta R Kashyap; Hope Barkoukis; John P Kirwan Journal: Ann Nutr Metab Date: 2012 Impact factor: 3.374
Authors: Joseph M Pappachan; Elias C Chacko; Ganesan Arunagirinathan; Rajagopalan Sriraman Journal: Int J Hypertens Date: 2011-03-22 Impact factor: 2.420
Authors: Tracey L Woodlief; Elvis A Carnero; Robert A Standley; Giovanna Distefano; Steve J Anthony; Gabe S Dubis; John M Jakicic; Joseph A Houmard; Paul M Coen; Bret H Goodpaster Journal: Obesity (Silver Spring) Date: 2015-11-05 Impact factor: 5.002