| Literature DB >> 19842689 |
Dong Jun Lee1, Kalyaneswar Mandal, Paul W R Harris, Margaret A Brimble, Stephen B H Kent.
Abstract
The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N(3) as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demonstrated.Entities:
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Year: 2009 PMID： 19842689 DOI： 10.1021/ol902131n
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005