| Literature DB >> 19836248 |
Lisa M Havran1, Dan C Chong, Wayne E Childers, Paul J Dollings, Arlene Dietrich, Boyd L Harrison, Vasilios Marathias, Gregory Tawa, Ann Aulabaugh, Rebecca Cowling, Bhupesh Kapoor, Weixin Xu, Lidia Mosyak, Franklin Moy, Wah-Tung Hum, Andrew Wood, Albert J Robichaud.
Abstract
Cysteine-dependant aspartyl protease (caspase) activation has been implicated as a part of the signal transduction pathway leading to apoptosis. It has been postulated that caspase-3 inhibition could attenuate cell damage after an ischemic event and thereby providing for a novel neuroprotective treatment for stroke. As part of a program to develop a small molecule inhibitor of caspase-3, a novel series of 3,4-dihydropyrimido(1,2-a)indol-10(2H)-ones (pyrimidoindolones) was identified. The synthesis, biological evaluation and structure-activity relationships of the pyrimidoindolones are described.Entities:
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Year: 2009 PMID： 19836248 DOI： 10.1016/j.bmc.2009.09.036
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641