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Literature DB >> 19827079

Apamin as a template for structure-based rational design of potent peptide activators of p53.

Chong Li¹, Marzena Pazgier, Min Liu, Wei-Yue Lu, Wuyuan Lu.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19827079 PMCID： PMC2845718 DOI： 10.1002/anie.200904550

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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28 in total

Review 1. Targeting protein-protein interactions: lessons from p53/MDM2.

Authors: Justin K Murray; Samuel H Gellman
Journal: Biopolymers Date: 2007 Impact factor: 2.505

2. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.

Authors: Anna Czarna; Grzegorz M Popowicz; Aleksandra Pecak; Siglinde Wolf; Grzegorz Dubin; Tad A Holak
Journal: Cell Cycle Date: 2009-04-16 Impact factor: 4.534

3. Designed high affinity Cu2+-binding alpha-helical foldamer.

Authors: Andrew J Nicoll; David J Miller; Klaus Fütterer; Raymond Ravelli; Rudolf K Allemann
Journal: J Am Chem Soc Date: 2006-07-19 Impact factor: 15.419

Review 4. p53 in health and disease.

Authors: Karen H Vousden; David P Lane
Journal: Nat Rev Mol Cell Biol Date: 2007-04 Impact factor: 94.444

Review 5. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.

Authors: Franck Toledo; Geoffrey M Wahl
Journal: Nat Rev Cancer Date: 2006-12 Impact factor: 60.716

6. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

Authors: Baoli Hu; Daniele M Gilkes; Jiandong Chen
Journal: Cancer Res Date: 2007-09-15 Impact factor: 12.701

7. Role of Asn(2) and Glu(7) residues in the oxidative folding and on the conformation of the N-terminal loop of apamin.

Authors: Dung Le-Nguyen; Laurent Chiche; François Hoh; Marie France Martin-Eauclaire; Christian Dumas; Yoshinori Nishi; Yuji Kobayashi; André Aumelas
Journal: Biopolymers Date: 2007 Aug 5-15 Impact factor: 2.505

8. Turning a scorpion toxin into an antitumor miniprotein.

Authors: Chong Li; Min Liu; Juahdi Monbo; Guozhang Zou; Changqing Li; Weirong Yuan; Davide Zella; Wei-Yue Lu; Wuyuan Lu
Journal: J Am Chem Soc Date: 2008-09-18 Impact factor: 15.419

9. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.

Authors: Sanjeev Shangary; Dongguang Qin; Donna McEachern; Meilan Liu; Rebecca S Miller; Su Qiu; Zaneta Nikolovska-Coleska; Ke Ding; Guoping Wang; Jianyong Chen; Denzil Bernard; Jian Zhang; Yipin Lu; Qingyang Gu; Rajal B Shah; Kenneth J Pienta; Xiaolan Ling; Sanmao Kang; Ming Guo; Yi Sun; Dajun Yang; Shaomeng Wang
Journal: Proc Natl Acad Sci U S A Date: 2008-03-03 Impact factor: 11.205

10. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Authors: Marzena Pazgier; Min Liu; Guozhang Zou; Weirong Yuan; Changqing Li; Chong Li; Jing Li; Juahdi Monbo; Davide Zella; Sergey G Tarasov; Wuyuan Lu
Journal: Proc Natl Acad Sci U S A Date: 2009-03-02 Impact factor: 11.205

19 in total

1. Limitations of peptide retro-inverso isomerization in molecular mimicry.

Authors: Chong Li; Marzena Pazgier; Jing Li; Changqing Li; Min Liu; Guozhang Zou; Zhenyu Li; Jiandong Chen; Sergey G Tarasov; Wei-Yue Lu; Wuyuan Lu
Journal: J Biol Chem Date: 2010-04-09 Impact factor: 5.157

2. A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation.

Authors: Xishan Chen; Lingyu Tai; Jie Gao; Jianchang Qian; Mingfei Zhang; Beibei Li; Cao Xie; Linwei Lu; Wuyuan Lu; Weiyue Lu
Journal: J Control Release Date: 2015-09-30 Impact factor: 9.776

3. Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.

Authors: Changyou Zhan; Kristen Varney; Weirong Yuan; Le Zhao; Wuyuan Lu
Journal: J Am Chem Soc Date: 2012-04-04 Impact factor: 15.419

Apamin as a template for structure-based rational design of potent peptide activators of p53.

Review 1. Targeting protein-protein interactions: lessons from p53/MDM2.

2. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.

3. Designed high affinity Cu2+-binding alpha-helical foldamer.

Review 4. p53 in health and disease.

Review 5. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.

6. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

7. Role of Asn(2) and Glu(7) residues in the oxidative folding and on the conformation of the N-terminal loop of apamin.

8. Turning a scorpion toxin into an antitumor miniprotein.

9. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.

10. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

1. Limitations of peptide retro-inverso isomerization in molecular mimicry.

2. A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation.

3. Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.

4. A left-handed solution to peptide inhibition of the p53-MDM2 interaction.

Review 5. The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.

6. Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.

Review 7. Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.

8. Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation.

9. Novel peptide-mediated interactions derived from high-resolution 3-dimensional structures.

10. Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.