Literature DB >> 19826677

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.

W Mei Kok1, Denis B Scanlon, John A Karas, Luke A Miles, Deborah J Tew, Michael W Parker, Kevin J Barnham, Craig A Hutton.   

Abstract

Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.

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Year:  2009        PMID： 19826677     DOI： 10.1039/b912784d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.

Authors:  Victor L Villemagne; Keyla A Perez; Kerryn E Pike; W Mei Kok; Christopher C Rowe; Anthony R White; Pierrick Bourgeat; Olivier Salvado; Justin Bedo; Craig A Hutton; Noel G Faux; Colin L Masters; Kevin J Barnham
Journal:  J Neurosci       Date:  2010-05-05       Impact factor: 6.167

2.  Captides: rigid junctions between beta sheets and small molecules.

Authors:  Brandon L Kier; Niels H Andersen
Journal:  J Pept Sci       Date:  2014-06-06       Impact factor: 1.905

3.  A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

Authors:  Brian O'Nuallain; Igor Klyubin; Jessica M Mc Donald; James S Foster; Alfred Welzel; Andrew Barry; Richard K Dykoski; James P Cleary; Martijn F B G Gebbink; Michael J Rowan; Dominic M Walsh
Journal:  J Neurochem       Date:  2011-08-22       Impact factor: 5.372

4.  Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.

Authors:  Brian O'Nuallain; Darragh B Freir; Andrew J Nicoll; Emmanuel Risse; Neil Ferguson; Caroline E Herron; John Collinge; Dominic M Walsh
Journal:  J Neurosci       Date:  2010-10-27       Impact factor: 6.167

5.  A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils.

Authors:  Sheng Zhang; Stan Yoo; Dalton T Snyder; Benjamin B Katz; Amy Henrickson; Borries Demeler; Vicki H Wysocki; Adam G Kreutzer; James S Nowick
Journal:  Biochemistry       Date:  2022-01-26       Impact factor: 3.321

6.  Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation.

Authors:  Kristy L Peck; Heather S Clewett; Jennifer C Schmitt; Jason Shearer
Journal:  Chem Commun (Camb)       Date:  2013-05-25       Impact factor: 6.222

7.  Synthetic dimeric Aβ(28-40) mimics the complex epitope of human anti-Aβ autoantibodies against toxic Aβ oligomers.

Authors:  Andreas M Roeder; Yvonne Roettger; Anne Stündel; Richard Dodel; Armin Geyer
Journal:  J Biol Chem       Date:  2013-07-11       Impact factor: 5.157

8.  An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.

Authors:  Jaslyn E M M Wong; Søren Roi Midtgaard; Kira Gysel; Mikkel B Thygesen; Kasper K Sørensen; Knud J Jensen; Jens Stougaard; Søren Thirup; Mickaël Blaise
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-02-26

9.  Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.

Authors:  Kazuma Murakami; Maki Tokuda; Takashi Suzuki; Yumi Irie; Mizuho Hanaki; Naotaka Izuo; Yoko Monobe; Ken-Ichi Akagi; Ryotaro Ishii; Harutsugu Tatebe; Takahiko Tokuda; Masahiro Maeda; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie
Journal:  Sci Rep       Date:  2016-07-04       Impact factor: 4.379

10.  Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer.

Authors:  Miao Gu; David C Bode; John H Viles
Journal:  Sci Rep       Date:  2018-11-01       Impact factor: 4.379
  10 in total

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