Literature DB >> 23608950

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation.

Kristy L Peck1, Heather S Clewett, Jennifer C Schmitt, Jason Shearer.   

Abstract

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.

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Year:  2013        PMID： 23608950      PMCID： PMC3697824          DOI： 10.1039/c3cc40326b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  Metals and Alzheimer's disease.

Authors:  Paul A Adlard; Ashley I Bush
Journal:  J Alzheimers Dis       Date:  2006-11       Impact factor: 4.472

2.  Amyloid beta-protein monomer structure: a computational and experimental study.

Authors:  Andrij Baumketner; Summer L Bernstein; Thomas Wyttenbach; Gal Bitan; David B Teplow; Michael T Bowers; Joan-Emma Shea
Journal:  Protein Sci       Date:  2006-03       Impact factor: 6.725

3.  Structural characterization of a soluble amyloid beta-peptide oligomer.

Authors:  Liping Yu; Rohinton Edalji; John E Harlan; Thomas F Holzman; Ana Pereda Lopez; Boris Labkovsky; Heinz Hillen; Stefan Barghorn; Ulrich Ebert; Paul L Richardson; Laura Miesbauer; Larry Solomon; Diane Bartley; Karl Walter; Robert W Johnson; Philip J Hajduk; Edward T Olejniczak
Journal:  Biochemistry       Date:  2009-03-10       Impact factor: 3.162

4.  Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes.

Authors:  Richard A Himes; Ga Young Park; Gnana Sutha Siluvai; Ninian J Blackburn; Kenneth D Karlin
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 5.  The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

Authors:  I W Hamley
Journal:  Chem Rev       Date:  2012-07-19       Impact factor: 60.622

6.  Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Authors:  Stefan Barghorn; Volker Nimmrich; Andreas Striebinger; Carsten Krantz; Patrick Keller; Bodo Janson; Michael Bahr; Martin Schmidt; Robert S Bitner; John Harlan; Eve Barlow; Ulrich Ebert; Heinz Hillen
Journal:  J Neurochem       Date:  2005-08-31       Impact factor: 5.372

7.  Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Authors:  Ganesh M Shankar; Shaomin Li; Tapan H Mehta; Amaya Garcia-Munoz; Nina E Shepardson; Imelda Smith; Francesca M Brett; Michael A Farrell; Michael J Rowan; Cynthia A Lemere; Ciaran M Regan; Dominic M Walsh; Bernardo L Sabatini; Dennis J Selkoe
Journal:  Nat Med       Date:  2008-06-22       Impact factor: 53.440

8.  The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide.

Authors:  Jason Shearer; Veronika A Szalai
Journal:  J Am Chem Soc       Date:  2008-12-31       Impact factor: 15.419

9.  Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry.

Authors:  Richard A Himes; Ga Young Park; Amanda N Barry; Ninian J Blackburn; Kenneth D Karlin
Journal:  J Am Chem Soc       Date:  2007-04-06       Impact factor: 15.419

10.  Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

Authors:  J C Janssen; J A Beck; T A Campbell; A Dickinson; N C Fox; R J Harvey; H Houlden; M N Rossor; J Collinge
Journal:  Neurology       Date:  2003-01-28       Impact factor: 9.910
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