Literature DB >> 1982295

Synthesis and pharmacological properties of nebivolol, a new antihypertensive compound.

G Van Lommen1, M De Bruyn, M Schroven.   

Abstract

The synthesis of alpha,alpha' (iminobis(methylene]-bis-(3,4-dihydro-2H-1benzopyran-2-metha nol) derivatives and the stereochemistry and pharmacological profile of this new class of antihypertensive compounds are described. Finally, the selection and pharmacological profile of the preferred compound of this series, nebivolol and its enantiomers, is discussed.

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Year:  1990        PMID： 1982295

Source DB:  PubMed          Journal:  J Pharm Belg        ISSN： 0047-2166


  6 in total

1.  Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates.

Authors:  Fei Liu; Todd Evans; Bhaskar C Das
Journal:  Tetrahedron Lett       Date:  2008-03-03       Impact factor: 2.415

2.  l-Nebiviololinium chloride dihydrate.

Authors:  Gisbert Tuchalski; Andre Hänsicke; Günther Reck; Franziska Emmerling
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

3.  Crystal structure of (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman.

Authors:  Yoann Rousselin; Hugo Laureano; Alexandre Clavel
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-08

4.  A triclinic polymorph of (-)-(S)-N-benzyl-2-[(R)-6-fluoro-chroman-2-yl]-2-hy-droxy-ethanaminium bromide.

Authors:  Yoann Rousselin; Hugo Laureano; Alexandre Clavel
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-20

5.  Studies directed toward the exploitation of vicinal diols in the synthesis of (+)-nebivolol intermediates.

Authors:  Runjun Devi; Sajal Kumar Das
Journal:  Beilstein J Org Chem       Date:  2017-03-21       Impact factor: 2.883

6.  (S,S,S,S)-Nebivolol hydro-chloride hemihydrate.

Authors:  Yoann Rousselin; Amelie Bruel; Alexandre Clavel
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-14
  6 in total

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