OBJECTIVE: To test the association between Tourette syndrome (TS) and genetic variants in genomic loci MEIS1, MAP2K5/LBXCOR1, and BTBD9, for which genome-wide association studies in restless legs syndrome and periodic limb movements during sleep revealed common risk variants. DESIGN: Case-control association study. SETTING: Movement disorder clinic in Montreal. Subjects We typed 14 single-nucleotide polymorphisms spanning the 3 genomic loci in 298 TS trios, 322 TS cases (including 298 probands from the cohort of TS trios), and 290 control subjects. MAIN OUTCOME MEASURES: Clinical diagnosis of TS, obsessive-compulsive disorder, and attention-deficit disorder. RESULTS: The study provided 3 single-nucleotide polymorphisms within BTBD9 associated with TS (chi(2) = 8.02 [P = .005] for rs9357271), with the risk alleles for restless legs syndrome and periodic limb movements during sleep overrepresented in the TS cohort. We stratified our group of patients with TS according to presence or absence of obsessive-compulsive disorder and/or attention-deficit disorder and found that variants in BTBD9 were strongly associated with TS without obsessive-compulsive disorder (chi(2) = 12.95 [P < .001] for rs9357271). Furthermore, allele frequency of rs9357271 inversely correlated with severity of obsessive-compulsive disorder as measured by the Yale-Brown Obsessive Compulsive Scale score. CONCLUSION: Variants in BTBD9 that predispose to restless legs syndrome and periodic limb movements during sleep are also associated with TS, particularly TS without obsessive-compulsive disorder.
OBJECTIVE: To test the association between Tourette syndrome (TS) and genetic variants in genomic loci MEIS1, MAP2K5/LBXCOR1, and BTBD9, for which genome-wide association studies in restless legs syndrome and periodic limb movements during sleep revealed common risk variants. DESIGN: Case-control association study. SETTING:Movement disorder clinic in Montreal. Subjects We typed 14 single-nucleotide polymorphisms spanning the 3 genomic loci in 298 TS trios, 322 TS cases (including 298 probands from the cohort of TS trios), and 290 control subjects. MAIN OUTCOME MEASURES: Clinical diagnosis of TS, obsessive-compulsive disorder, and attention-deficit disorder. RESULTS: The study provided 3 single-nucleotide polymorphisms within BTBD9 associated with TS (chi(2) = 8.02 [P = .005] for rs9357271), with the risk alleles for restless legs syndrome and periodic limb movements during sleep overrepresented in the TS cohort. We stratified our group of patients with TS according to presence or absence of obsessive-compulsive disorder and/or attention-deficit disorder and found that variants in BTBD9 were strongly associated with TS without obsessive-compulsive disorder (chi(2) = 12.95 [P < .001] for rs9357271). Furthermore, allele frequency of rs9357271 inversely correlated with severity of obsessive-compulsive disorder as measured by the Yale-Brown Obsessive Compulsive Scale score. CONCLUSION: Variants in BTBD9 that predispose to restless legs syndrome and periodic limb movements during sleep are also associated with TS, particularly TS without obsessive-compulsive disorder.
Authors: Emily J Ricketts; Gabrielle E Montalbano; Helen J Burgess; Dana L McMakin; Meredith E Coles; John Piacentini; Christopher S Colwell Journal: J Clin Psychol Date: 2022-02-12
Authors: Mohamed Abdulkadir; Douglas Londono; Derek Gordon; Thomas V Fernandez; Lawrence W Brown; Keun-Ah Cheon; Barbara J Coffey; Lonneke Elzerman; Carolin Fremer; Odette Fründt; Blanca Garcia-Delgar; Donald L Gilbert; Dorothy E Grice; Tammy Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Ewgeni Jakubovski; Young Key Kim; Young Shin Kim; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Bennett Leventhal; Andrea G Ludolph; Marcos Madruga-Garrido; Athanasios Maras; Pablo Mir; Astrid Morer; Kirsten Müller-Vahl; Alexander Münchau; Tara L Murphy; Kerstin J Plessen; Veit Roessner; Eun-Young Shin; Dong-Ho Song; Jungeun Song; Jennifer Tübing; Els van den Ban; Frank Visscher; Sina Wanderer; Martin Woods; Samuel H Zinner; Robert A King; Jay A Tischfield; Gary A Heiman; Pieter J Hoekstra; Andrea Dietrich Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-05-29 Impact factor: 5.270
Authors: S E Stewart; D Yu; J M Scharf; B M Neale; J A Fagerness; C A Mathews; P D Arnold; P D Evans; E R Gamazon; L K Davis; L Osiecki; L McGrath; S Haddad; J Crane; D Hezel; C Illman; C Mayerfeld; A Konkashbaev; C Liu; A Pluzhnikov; A Tikhomirov; C K Edlund; S L Rauch; R Moessner; P Falkai; W Maier; S Ruhrmann; H-J Grabe; L Lennertz; M Wagner; L Bellodi; M C Cavallini; M A Richter; E H Cook; J L Kennedy; D Rosenberg; D J Stein; S M J Hemmings; C Lochner; A Azzam; D A Chavira; E Fournier; H Garrido; B Sheppard; P Umaña; D L Murphy; J R Wendland; J Veenstra-VanderWeele; D Denys; R Blom; D Deforce; F Van Nieuwerburgh; H G M Westenberg; S Walitza; K Egberts; T Renner; E C Miguel; C Cappi; A G Hounie; M Conceição do Rosário; A S Sampaio; H Vallada; H Nicolini; N Lanzagorta; B Camarena; R Delorme; M Leboyer; C N Pato; M T Pato; E Voyiaziakis; P Heutink; D C Cath; D Posthuma; J H Smit; J Samuels; O J Bienvenu; B Cullen; A J Fyer; M A Grados; B D Greenberg; J T McCracken; M A Riddle; Y Wang; V Coric; J F Leckman; M Bloch; C Pittenger; V Eapen; D W Black; R A Ophoff; E Strengman; D Cusi; M Turiel; F Frau; F Macciardi; J R Gibbs; M R Cookson; A Singleton; J Hardy; A T Crenshaw; M A Parkin; D B Mirel; D V Conti; S Purcell; G Nestadt; G L Hanna; M A Jenike; J A Knowles; N Cox; D L Pauls Journal: Mol Psychiatry Date: 2012-08-14 Impact factor: 15.992