The first 83 and the next 83: perspectives on neurotoxicology.

This commentary depicts the author's history, and how it became interwoven with neurotoxicology. Born in 1925, most of his life spanned a century burdened with calamitous wars as well as revolutionary developments in science. Aviation played a large role in the century's wars and in the author's outlook on the world. He moved from a literary perspective, after his war experiences, to one governed by science, his earliest bent. During his career, which embodied the early development of both behavioral pharmacology and behavioral toxicology, he emphasized the critical need for precise measures, a point of view illustrated by his adoption of digital computer technology in 1962 as a means to secure such measures. The commentary also describes the author's views of some of the new directions open to neurotoxicology, such as the pursuit of questions about endocrine disruptors, countermeasures for brain aging, and epigenetics.