Literature DB >> 19819907

The NIH Human Microbiome Project.

Jane Peterson, Susan Garges, Maria Giovanni, Pamela McInnes, Lu Wang, Jeffery A Schloss, Vivien Bonazzi, Jean E McEwen, Kris A Wetterstrand, Carolyn Deal, Carl C Baker, Valentina Di Francesco, T Kevin Howcroft, Robert W Karp, R Dwayne Lunsford, Christopher R Wellington, Tsegahiwot Belachew, Michael Wright, Christina Giblin, Hagit David, Melody Mills, Rachelle Salomon, Christopher Mullins, Beena Akolkar, Lisa Begg, Cindy Davis, Lindsey Grandison, Michael Humble, Jag Khalsa, A Roger Little, Hannah Peavy, Carol Pontzer, Matthew Portnoy, Michael H Sayre, Pamela Starke-Reed, Samir Zakhari, Jennifer Read, Bracie Watson, Mark Guyer.   

Abstract

The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal" volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.

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Year:  2009        PMID: 19819907      PMCID: PMC2792171          DOI: 10.1101/gr.096651.109

Source DB:  PubMed          Journal:  Genome Res        ISSN: 1088-9051            Impact factor:   9.043


  29 in total

1.  In a map for human life, count the microbes, too.

Authors:  J Davies
Journal:  Science       Date:  2001-03-23       Impact factor: 47.728

Review 2.  Metagenomics: DNA sequencing of environmental samples.

Authors:  Susannah Green Tringe; Edward M Rubin
Journal:  Nat Rev Genet       Date:  2005-11       Impact factor: 53.242

Review 3.  Metagenomics: application of genomics to uncultured microorganisms.

Authors:  Jo Handelsman
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

4.  Molecular analysis of human forearm superficial skin bacterial biota.

Authors:  Zhan Gao; Chi-hong Tseng; Zhiheng Pei; Martin J Blaser
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-09       Impact factor: 11.205

5.  Phylogenetic structure of the prokaryotic domain: the primary kingdoms.

Authors:  C R Woese; G E Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

6.  Microbes on the human vaginal epithelium.

Authors:  Richard W Hyman; Marilyn Fukushima; Lisa Diamond; Jochen Kumm; Linda C Giudice; Ronald W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-23       Impact factor: 11.205

7.  Genetic diversity in Sargasso Sea bacterioplankton.

Authors:  S J Giovannoni; T B Britschgi; C L Moyer; K G Field
Journal:  Nature       Date:  1990-05-03       Impact factor: 49.962

8.  Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods.

Authors:  Xia Zhou; Stephen J Bent; Maria G Schneider; Catherine C Davis; Mohammed R Islam; Larry J Forney
Journal:  Microbiology (Reading)       Date:  2004-08       Impact factor: 2.777

9.  Bacterial biota in the human distal esophagus.

Authors:  Zhiheng Pei; Edmund J Bini; Liying Yang; Meisheng Zhou; Fritz Francois; Martin J Blaser
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-11       Impact factor: 11.205

10.  Development of the human infant intestinal microbiota.

Authors:  Chana Palmer; Elisabeth M Bik; Daniel B DiGiulio; David A Relman; Patrick O Brown
Journal:  PLoS Biol       Date:  2007-06-26       Impact factor: 8.029

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  711 in total

1.  Distance burning: how gut microbes promote extraintestinal cancers.

Authors:  Arlin B Rogers
Journal:  Gut Microbes       Date:  2011 Jan-Feb

Review 2.  The microbiota of the vagina and its influence on women's health and disease.

Authors:  David H Martin
Journal:  Am J Med Sci       Date:  2012-01       Impact factor: 2.378

3.  Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches.

Authors:  Maureen A O'Malley; Karola Stotz
Journal:  Philos Ethics Humanit Med       Date:  2011-01-28       Impact factor: 2.464

Review 4.  Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective.

Authors:  Rebecca M Brotman
Journal:  J Clin Invest       Date:  2011-12-01       Impact factor: 14.808

Review 5.  Techniques used to characterize the gut microbiota: a guide for the clinician.

Authors:  Marianne H Fraher; Paul W O'Toole; Eamonn M M Quigley
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-03-27       Impact factor: 46.802

Review 6.  The potter's wheel: the host's role in sculpting its microbiota.

Authors:  Charles L Bevins; Nita H Salzman
Journal:  Cell Mol Life Sci       Date:  2011-10-04       Impact factor: 9.261

7.  A de Bruijn graph approach to the quantification of closely-related genomes in a microbial community.

Authors:  Mingjie Wang; Yuzhen Ye; Haixu Tang
Journal:  J Comput Biol       Date:  2012-06       Impact factor: 1.479

8.  Ecological adaptation in bacteria: speciation driven by codon selection.

Authors:  Adam C Retchless; Jeffrey G Lawrence
Journal:  Mol Biol Evol       Date:  2012-06-26       Impact factor: 16.240

9.  Human papillomavirus community in healthy persons, defined by metagenomics analysis of human microbiome project shotgun sequencing data sets.

Authors:  Yingfei Ma; Ramana Madupu; Ulas Karaoz; Carlos W Nossa; Liying Yang; Shibu Yooseph; Patrick S Yachimski; Eoin L Brodie; Karen E Nelson; Zhiheng Pei
Journal:  J Virol       Date:  2014-02-12       Impact factor: 5.103

10.  BReast Ecology Assessment in the STudy of local MicroFlora - Study Protocol.

Authors:  Dana Mihaela Jianu; Anca Streinu-Cercel; Alexandru Blidaru; Maria Filipescu; Ioan Petre Florescu; Ioana Berciu; Oltjon Cobani; Olga Dorobăţ; Stefan Adrian Jianu; Oana Streinu-Cercel; Floria Stăniceanu; Adrian Streinu-Cercel
Journal:  Germs       Date:  2013-03-01
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