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Literature DB >> 19817465

Secondary metabolomics: natural products mass spectrometry goes global.

Abstract

A global LC-MS metabolite analysis of wild-type Pseudomonas auerigunosa and mutants targeting the natural product pyochelin revealed the production of previously unknown metabolites, the 2-alkyl-4,5-dihydrothiazole-4-carboxylates.

Entities: Chemical

Mesh：

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Year: 2009 PMID： 19817465 DOI： 10.1021/cb900187p

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

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Cited

7 in total

Review 1. Emerging applications of metabolomics in studying chemopreventive phytochemicals.

Authors: Lei Wang; Chi Chen
Journal: AAPS J Date: 2013-06-22 Impact factor: 4.009

2. Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library.

Authors: Jae Kyoung Lee; Jae-Hyuk Jang; Dong-Jin Park; Chang-Jin Kim; Jong Seog Ahn; Bang Yeon Hwang; Young-Soo Hong
Journal: J Antibiot (Tokyo) Date: 2016-12-21 Impact factor: 2.649

3. KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.

Authors: Claire A Knoten; L Lynn Hudson; James P Coleman; John M Farrow; Everett C Pesci
Journal: J Bacteriol Date: 2011-09-30 Impact factor: 3.490

Review 4. Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.

Authors: Lindsay K Caesar; Rana Montaser; Nancy P Keller; Neil L Kelleher
Journal: Nat Prod Rep Date: 2021-11-17 Impact factor: 13.423

Secondary metabolomics: natural products mass spectrometry goes global.

Review 1. Emerging applications of metabolomics in studying chemopreventive phytochemicals.

2. Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library.

3. KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.

Review 4. Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.

5. Microbial strain prioritization using metabolomics tools for the discovery of natural products.

Review 6. Metabolic profiling as a tool for prioritizing antimicrobial compounds.

7. A systems approach using OSMAC, Log P and NMR fingerprinting: An approach to novelty.