Literature DB >> 19815179

Role of spindle asymmetry in cellular dynamics.

Yves Barral1, Dimitris Liakopoulos.   

Abstract

The mitotic spindle is mostly perceived as a symmetric structure. However, in many cell divisions, the two poles of the spindle organize asters with different dynamics, associate with different biomolecules or subcellular domains, and perform different functions. In this chapter, we describe some of the most prominent examples of spindle asymmetry. These are encountered during cell-cycle progression in budding and fission yeast and during asymmetric cell divisions of stem cells and embryos. We analyze the molecular mechanisms that lead to generation of spindle asymmetry and discuss the importance of spindle-pole differentiation for the correct outcome of cell division.

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Year:  2009        PMID： 19815179     DOI： 10.1016/S1937-6448(09)78004-9

Source DB:  PubMed          Journal:  Int Rev Cell Mol Biol        ISSN： 1937-6448            Impact factor:   6.813


  12 in total

1.  Spatiotemporal analysis of organelle and macromolecular complex inheritance.

Authors:  Victoria Menendez-Benito; Sjoerd J van Deventer; Victor Jimenez-Garcia; Marina Roy-Luzarraga; Fred van Leeuwen; Jacques Neefjes
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205

2.  The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.

Authors:  Manuel Hotz; Jette Lengefeld; Yves Barral
Journal:  Cell Cycle       Date:  2012-08-08       Impact factor: 4.534

3.  Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation.

Authors:  Manuel Hotz; Christian Leisner; Daici Chen; Cristina Manatschal; Thomas Wegleiter; Jimmy Ouellet; Derek Lindstrom; Dan E Gottschling; Jackie Vogel; Yves Barral
Journal:  Cell       Date:  2012-03-02       Impact factor: 41.582

Review 4.  Fly meets yeast: checking the correct orientation of cell division.

Authors:  Gislene Pereira; Yukiko M Yamashita
Journal:  Trends Cell Biol       Date:  2011-06-24       Impact factor: 20.808

5.  Septin-containing barriers control the differential inheritance of cytoplasmic elements.

Authors:  Alan Michael Tartakoff; Ilya Aylyarov; Purnima Jaiswal
Journal:  Cell Rep       Date:  2012-12-27       Impact factor: 9.423

Review 6.  Yeast evolutionary genomics.

Authors:  Bernard Dujon
Journal:  Nat Rev Genet       Date:  2010-07       Impact factor: 53.242

7.  Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.

Authors:  Jiun-Ming Wu; Chiung-Tong Chen; Mohane Selvaraj Coumar; Wen-Hsin Lin; Zi-Jie Chen; John T-A Hsu; Yi-Hui Peng; Hui-Yi Shiao; Wen-Hsing Lin; Chang-Ying Chu; Jian-Sung Wu; Chih-Tsung Lin; Ching-Ping Chen; Ching-Cheng Hsueh; Kai-Yen Chang; Li-Pin Kao; Chi-Ying F Huang; Yu-Sheng Chao; Su-Ying Wu; Hsing-Pang Hsieh; Ya-Hui Chi
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-22       Impact factor: 11.205

8.  Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8.

Authors:  Yusuke Fukuda; Anna Luchniak; Erin R Murphy; Mohan L Gupta
Journal:  Curr Biol       Date:  2014-07-31       Impact factor: 10.834

9.  Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Authors:  Juan Carlos G Cortés; Mamiko Sato; Javier Muñoz; M Belén Moreno; Jose Angel Clemente-Ramos; Mariona Ramos; Hitoshi Okada; Masako Osumi; Angel Durán; Juan Carlos Ribas
Journal:  J Cell Biol       Date:  2012-08-13       Impact factor: 10.539

Review 10.  Organelle segregation during mitosis: lessons from asymmetrically dividing cells.

Authors:  Jimmy Ouellet; Yves Barral
Journal:  J Cell Biol       Date:  2012-02-06       Impact factor: 10.539
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