PURPOSE: Intraosseous hemangioma of the mandible is a rare tumor. In this report, we present a case with a particularly prominent osteolysis and discuss the histological features of bone degradation. MATERIALS AND METHODS: We describe a 64-year-old female patient with a cystic tumor mass of the mandible leading to pathologic bone fracture. X-ray analysis was suggestive for aneurysmatic bone cyst. A segment resection was performed. RESULTS: The histological examination revealed a mesenchymal tumor with numerous capillaries and dilated vessels immunohistochemically being positive for CD31, but not for D2-40. In addition, there was a remarkable increase of osteoclasts that sometimes exhibited Howship's lacunae. The tumor was diagnosed as intraosseous hemangioma with prominent bone degradation. CONCLUSIONS: Based on our histological findings, it should be further investigated whether there could be an association between angiogenesis and osteoclastogenesis as a central pathway leading to bone destruction in the case of intraosseous hemangiomas.
PURPOSE:Intraosseous hemangioma of the mandible is a rare tumor. In this report, we present a case with a particularly prominent osteolysis and discuss the histological features of bone degradation. MATERIALS AND METHODS: We describe a 64-year-old female patient with a cystic tumor mass of the mandible leading to pathologic bone fracture. X-ray analysis was suggestive for aneurysmatic bone cyst. A segment resection was performed. RESULTS: The histological examination revealed a mesenchymal tumor with numerous capillaries and dilated vessels immunohistochemically being positive for CD31, but not for D2-40. In addition, there was a remarkable increase of osteoclasts that sometimes exhibited Howship's lacunae. The tumor was diagnosed as intraosseous hemangioma with prominent bone degradation. CONCLUSIONS: Based on our histological findings, it should be further investigated whether there could be an association between angiogenesis and osteoclastogenesis as a central pathway leading to bone destruction in the case of intraosseous hemangiomas.
Authors: Silvia Colucci; Giulia Taraboletti; Luca Primo; Andrea Viale; Cristina Roca; Donatella Valdembri; Massimo Geuna; Marco Pagano; Maria Grano; Anthony M Pogrel; Adrian L Harris; Nicholas N Athanasou; Alberto Mantovani; Alberta Zallone; Federico Bussolino Journal: J Bone Miner Res Date: 2005-10-31 Impact factor: 6.741