OBJECTIVE AND DESIGN: The aim of this study was to assess the value of procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1b, IL-8, and soluble TNF receptor II (sTNFRII) in early and rapid diagnosis of infection in neutropenic children with acute lymphoblastic leukemia (ALL) and to distinguish bacterial from viral infections. PATIENTS: The study included five groups (A, B, C, D, and E) of children with ALL undergoing intensive chemotherapy. Groups A and B consisted of neutropenic children with bacterial and viral infection, respectively. Groups C and D consisted of nonneutropenic children with bacterial and viral infection, respectively. Group E consisted of children without neutropenia and without fever. METHODS: In all groups, blood samples were collected upon admission and then for 7 days on a daily basis. Levels of CRP, PCT, TNF-a, IL-1b, IL-8, and sTNFRII were determined in all blood samples. RESULTS: We found a highly significant difference in PCT levels between bacterial and nonbacterial episodes. Sensitivity and specificity of PCT were 94 and 96.5%, respectively. CONCLUSIONS: Serial measurement of PCT levels on a daily basis seems to be helpful for early prediction of severe bacterial infections, monitoring febrile episodes regarding response to antibiotic therapy, and early detection of complications in the infectious process.
OBJECTIVE AND DESIGN: The aim of this study was to assess the value of procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1b, IL-8, and soluble TNF receptor II (sTNFRII) in early and rapid diagnosis of infection in neutropenicchildren with acute lymphoblastic leukemia (ALL) and to distinguish bacterial from viral infections. PATIENTS: The study included five groups (A, B, C, D, and E) of children with ALL undergoing intensive chemotherapy. Groups A and B consisted of neutropenicchildren with bacterial and viral infection, respectively. Groups C and D consisted of nonneutropenic children with bacterial and viral infection, respectively. Group E consisted of children without neutropenia and without fever. METHODS: In all groups, blood samples were collected upon admission and then for 7 days on a daily basis. Levels of CRP, PCT, TNF-a, IL-1b, IL-8, and sTNFRII were determined in all blood samples. RESULTS: We found a highly significant difference in PCT levels between bacterial and nonbacterial episodes. Sensitivity and specificity of PCT were 94 and 96.5%, respectively. CONCLUSIONS: Serial measurement of PCT levels on a daily basis seems to be helpful for early prediction of severe bacterial infections, monitoring febrile episodes regarding response to antibiotic therapy, and early detection of complications in the infectious process.
Authors: Mirjam Christ-Crain; Daiana Jaccard-Stolz; Roland Bingisser; Mikael M Gencay; Peter R Huber; Michael Tamm; Beat Müller Journal: Lancet Date: 2004-02-21 Impact factor: 79.321
Authors: W T Hughes; D Armstrong; G P Bodey; A E Brown; J E Edwards; R Feld; P Pizzo; K V Rolston; J L Shenep; L S Young Journal: Clin Infect Dis Date: 1997-09 Impact factor: 9.079
Authors: S Hitoglou-Hatzi; M Hatzistilianou; D Gougoustamou; A Rekliti; Ch Agguridaki; F Athanassiadou; S Frydas; A Kotsis; D Catriu Journal: Clin Exp Med Date: 2005-07 Impact factor: 3.984
Authors: S Harbarth; K Holeckova; C Froidevaux; D Pittet; B Ricou; G E Grau; L Vadas; J Pugin Journal: Am J Respir Crit Care Med Date: 2001-08-01 Impact factor: 21.405
Authors: G N Matwiyoff; J D Prahl; R J Miller; J J Carmichael; D E Amundson; G Seda; M Daheshia Journal: Inflamm Res Date: 2012-02-22 Impact factor: 4.575
Authors: Luis García de Guadiana-Romualdo; Ignacio Español-Morales; Pablo Cerezuela-Fuentes; Luciano Consuegra-Sánchez; Ana Hernando-Holgado; Patricia Esteban-Torrella; Enrique Jiménez-Santos; Monserrat Viqueira-González; África de Béjar-Almira; María Dolores Albaladejo-Otón Journal: Support Care Cancer Date: 2015-01-07 Impact factor: 3.603
Authors: W J Heinz; D Buchheidt; M Christopeit; M von Lilienfeld-Toal; O A Cornely; H Einsele; M Karthaus; H Link; R Mahlberg; S Neumann; H Ostermann; O Penack; M Ruhnke; M Sandherr; X Schiel; J J Vehreschild; F Weissinger; G Maschmeyer Journal: Ann Hematol Date: 2017-08-30 Impact factor: 3.673
Authors: Hilde T van der Galiën; Erik A H Loeffen; Karin G E Miedema; Wim J E Tissing Journal: Support Care Cancer Date: 2018-05-19 Impact factor: 3.603