BACKGROUND: Conflicting data regarding exercise capacity and obstructive sleep apnea (OSA) have been published, which may be partially explained by the difficulty of controlling all of the confounding factors. The aim of this study is to evaluate the exercise, anthropometric, and blood parameters in lean, sedentary patients with OSA compared with controls. METHODS: Fifty-four lean subjects (including 27 patients with OSA and 27 controls) were selected. The control group was matched for age and gender. All subjects underwent polysomnography, anthropometric measures, a cardiorespiratory exercise test, two-dimensional transthoracic echocardiography, and spirometry. RESULTS: The mean age was 52.9 +/- 7.9 years in subjects with OSA and 52.8 +/- 8.1 years in controls (P = .95). The cervical circumference was greater in the lean OSA group when compared with the controls (33.7 +/- 3.5 cm vs 31.4 +/- 2.8 cm; P = .01). There were statistical differences in the apnea-hypopnea index, minimal oxygen saturation, and mean oxygen saturation in the lean patients with OSA. Glycemia was higher in the lean OSA group (115.1 +/- 50.1 mg/dL vs 94.2 +/- 9.8 mg/dL; P = .04). There were no differences between groups in the peak oxygen consumption (Vo(2)), anaerobic threshold (AT), respiratory exchange ratio (RER), BP, and heart rate. CONCLUSION: High glycemia and cervical circumference enlargement are the main characteristics of lean patients with OSA. Exercise performance is similar between groups, considering the peak Vo(2), AT, and RER. These results suggest that OSA does not impair functional capacity in lean subjects and that obesity probably participates in the diminished cardiopulmonary capacity observed in patients with OSA.
BACKGROUND: Conflicting data regarding exercise capacity and obstructive sleep apnea (OSA) have been published, which may be partially explained by the difficulty of controlling all of the confounding factors. The aim of this study is to evaluate the exercise, anthropometric, and blood parameters in lean, sedentary patients with OSA compared with controls. METHODS: Fifty-four lean subjects (including 27 patients with OSA and 27 controls) were selected. The control group was matched for age and gender. All subjects underwent polysomnography, anthropometric measures, a cardiorespiratory exercise test, two-dimensional transthoracic echocardiography, and spirometry. RESULTS: The mean age was 52.9 +/- 7.9 years in subjects with OSA and 52.8 +/- 8.1 years in controls (P = .95). The cervical circumference was greater in the lean OSA group when compared with the controls (33.7 +/- 3.5 cm vs 31.4 +/- 2.8 cm; P = .01). There were statistical differences in the apnea-hypopnea index, minimal oxygen saturation, and mean oxygen saturation in the lean patients with OSA. Glycemia was higher in the lean OSA group (115.1 +/- 50.1 mg/dL vs 94.2 +/- 9.8 mg/dL; P = .04). There were no differences between groups in the peak oxygen consumption (Vo(2)), anaerobic threshold (AT), respiratory exchange ratio (RER), BP, and heart rate. CONCLUSION:High glycemia and cervical circumference enlargement are the main characteristics of lean patients with OSA. Exercise performance is similar between groups, considering the peak Vo(2), AT, and RER. These results suggest that OSA does not impair functional capacity in lean subjects and that obesity probably participates in the diminished cardiopulmonary capacity observed in patients with OSA.
Authors: Adília Karoline Ferreira Souza; Armèle Dornelas de Andrade; Ana Irene Carlos de Medeiros; Maria Inês Remígio de Aguiar; Taciano Dias de Souza Rocha; Rodrigo Pinto Pedrosa; Anna Myrna Jaguaribe de Lima Journal: Sleep Breath Date: 2017-11-09 Impact factor: 2.816
Authors: Martinha Millianny Barros de Carvalho; Ricardo Quental Coutinho; Isly Maria L Barros; Laura O B F Costa; Ana Kelley L Medeiros; Thais C Lustosa; Carolina A Medeiros; Marcus Vinícius França; Tarcya L G Couto; Ulisses R Montarroyos; Virend K Somers; Rodrigo Pinto Pedrosa Journal: J Clin Sleep Med Date: 2018-09-15 Impact factor: 4.062
Authors: Amanda L Sharpe; Mary Ann Andrade; Myrna Herrera-Rosales; Steven L Britton; Lauren G Koch; Glenn M Toney Journal: Am J Physiol Heart Circ Physiol Date: 2013-05-24 Impact factor: 4.733
Authors: Meghna P Mansukhani; Thomas G Allison; Francisco Lopez-Jimenez; Virend K Somers; Sean M Caples Journal: Am J Cardiol Date: 2013-04-08 Impact factor: 2.778