Literature DB >> 19801413

Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme.

Rong Shi1, Magda Villarroya, Rafael Ruiz-Partida, Yunge Li, Ariane Proteau, Silvia Prado, Ismaïl Moukadiri, Alfonso Benítez-Páez, Rodrigo Lomas, John Wagner, Allan Matte, Adrián Velázquez-Campoy, M-Eugenia Armengod, Miroslaw Cygler.   

Abstract

The MnmE-MnmG complex is involved in tRNA modification. We have determined the crystal structure of Escherichia coli MnmG at 2.4-A resolution, mutated highly conserved residues with putative roles in flavin adenine dinucleotide (FAD) or tRNA binding and MnmE interaction, and analyzed the effects of these mutations in vivo and in vitro. Limited trypsinolysis of MnmG suggests significant conformational changes upon FAD binding.

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Year:  2009        PMID： 19801413      PMCID： PMC2786596          DOI： 10.1128/JB.00650-09

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  7 in total

1.  Crystal structure of the small form of glucose-inhibited division protein A from Thermus thermophilus HB8.

Authors:  Wakana Iwasaki; Hideyuki Miyatake; Kunio Miki
Journal:  Proteins       Date:  2005-12-01

2.  Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification.

Authors:  Marta Martínez-Vicente; Lucía Yim; Magda Villarroya; Mara Mellado; Enrique Pérez-Payá; Glenn R Björk; M-Eugenia Armengod
Journal:  J Biol Chem       Date:  2005-06-27       Impact factor: 5.157

3.  The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function.

Authors:  Lucía Yim; Marta Martínez-Vicente; Magdalena Villarroya; Carmen Aguado; Erwin Knecht; María-Eugenia Armengod
Journal:  J Biol Chem       Date:  2003-04-30       Impact factor: 5.157

4.  Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.

Authors:  S Meyer; A Scrima; W Versées; A Wittinghofer
Journal:  J Mol Biol       Date:  2008-05-07       Impact factor: 5.469

5.  Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria--evolutionary implications.

Authors:  Jaunius Urbonavicius; Stéphane Skouloubris; Hannu Myllykallio; Henri Grosjean
Journal:  Nucleic Acids Res       Date:  2005-07-18       Impact factor: 16.971

6.  Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli.

Authors:  Lucía Yim; Ismaïl Moukadiri; Glenn R Björk; M-Eugenia Armengod
Journal:  Nucleic Acids Res       Date:  2006-10-24       Impact factor: 16.971

7.  MODOMICS: a database of RNA modification pathways. 2008 update.

Authors:  Anna Czerwoniec; Stanislaw Dunin-Horkawicz; Elzbieta Purta; Katarzyna H Kaminska; Joanna M Kasprzak; Janusz M Bujnicki; Henri Grosjean; Kristian Rother
Journal:  Nucleic Acids Res       Date:  2008-10-14       Impact factor: 16.971
  7 in total
  23 in total

1.  Stabilization of G domain conformations in the tRNA-modifying MnmE-GidA complex observed with double electron electron resonance spectroscopy.

Authors:  Sabine Böhme; Simon Meyer; André Krüger; Heinz-Jürgen Steinhoff; Alfred Wittinghofer; Johann P Klare
Journal:  J Biol Chem       Date:  2010-03-30       Impact factor: 5.157

2.  Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli.

Authors:  Aya Kitamura; Toru Sengoku; Madoka Nishimoto; Shigeyuki Yokoyama; Yoshitaka Bessho
Journal:  Protein Sci       Date:  2011-06-02       Impact factor: 6.725

3.  Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.

Authors:  Daniele Ghezzi; Enrico Baruffini; Tobias B Haack; Federica Invernizzi; Laura Melchionda; Cristina Dallabona; Tim M Strom; Rossella Parini; Alberto B Burlina; Thomas Meitinger; Holger Prokisch; Ileana Ferrero; Massimo Zeviani
Journal:  Am J Hum Genet       Date:  2012-05-17       Impact factor: 11.025

4.  MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.

Authors:  Christin Tischner; Annette Hofer; Veronika Wulff; Joanna Stepek; Iulia Dumitru; Lore Becker; Tobias Haack; Laura Kremer; Alexandre N Datta; Wolfgang Sperl; Thomas Floss; Wolfgang Wurst; Zofia Chrzanowska-Lightowlers; Martin Hrabe De Angelis; Thomas Klopstock; Holger Prokisch; Tina Wenz
Journal:  Hum Mol Genet       Date:  2014-12-30       Impact factor: 6.150

5.  Insights into folate/FAD-dependent tRNA methyltransferase mechanism: role of two highly conserved cysteines in catalysis.

Authors:  Djemel Hamdane; Manuela Argentini; David Cornu; Hannu Myllykallio; Stéphane Skouloubris; Gaston Hui-Bon-Hoa; Béatrice Golinelli-Pimpaneau
Journal:  J Biol Chem       Date:  2011-08-16       Impact factor: 5.157

6.  Biocatalytic Reversal of Advanced Glycation End Product Modification.

Authors:  Nam Y Kim; Tyler N Goddard; Seungjung Sohn; David A Spiegel; Jason M Crawford
Journal:  Chembiochem       Date:  2019-08-09       Impact factor: 3.164

7.  Posttranscriptional regulation of 2,4-diacetylphloroglucinol production by GidA and TrmE in Pseudomonas fluorescens 2P24.

Authors:  Wei Zhang; Zhao Zhao; Bo Zhang; Xiao-Gang Wu; Zheng-Guang Ren; Li-Qun Zhang
Journal:  Appl Environ Microbiol       Date:  2014-04-18       Impact factor: 4.792

Review 8.  Overcoming Challenges in Engineering the Genetic Code.

Authors:  M J Lajoie; D Söll; G M Church
Journal:  J Mol Biol       Date:  2015-09-05       Impact factor: 5.469

9.  GidA expression in Salmonella is modulated under certain environmental conditions.

Authors:  Jaclyn M Rehl; Daniel C Shippy; Nicholas M Eakley; Megan D Brevik; Jordan M Sand; Mark E Cook; Amin A Fadl
Journal:  Curr Microbiol       Date:  2013-04-12       Impact factor: 2.188

10.  Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1).

Authors:  Aya Kitamura; Madoka Nishimoto; Toru Sengoku; Rie Shibata; Gunilla Jäger; Glenn R Björk; Henri Grosjean; Shigeyuki Yokoyama; Yoshitaka Bessho
Journal:  J Biol Chem       Date:  2012-10-22       Impact factor: 5.157
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