| Literature DB >> 19800697 |
Charity Onore1, Amanda Enstrom, Paula Krakowiak, Irva Hertz-Picciotto, Robin Hansen, Judy Van de Water, Paul Ashwood.
Abstract
A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.Entities:
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Year: 2009 PMID： 19800697 PMCID： PMC2981175 DOI： 10.1016/j.jneuroim.2009.09.005
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478