| Literature DB >> 26298322 |
Marjannie Eloi Akintunde1, Melissa Rose2, Paula Krakowiak3, Luke Heuer4, Paul Ashwood5, Robin Hansen6, Irva Hertz-Picciotto2, Judy Van de Water7.
Abstract
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.Entities:
Keywords: Asthma; Autism; Food allergies; IL-17
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Year: 2015 PMID： 26298322 PMCID： PMC4548834 DOI： 10.1016/j.jneuroim.2015.07.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478