BACKGROUND: The accuracy of magnetic resonance imaging (MRI) in identifying residual disease after breast conservation therapy (BCT) is unclear. METHOD: Review of an institutional database identified patients with positive or close (<or=2 mm) margins undergoing MRI before re-excision. Histopathologic correlation was performed. RESULTS: Forty-three women underwent MRI after BCT. MRI suggested residual disease in 29 patients, of whom 20 (69%) had residual carcinoma pathologically. Nine patients had false-positive MRI as seen by benign pathology findings. Fourteen MRIs indicated no residual disease, of which 6 had residual disease pathologically. The sensitivity and positive predictive value of MRI was 77% and 69%, respectively. MRI conducted within 28 days of the original surgery was 85% sensitive. MRI performed after 28 days was 69% sensitive. CONCLUSIONS: MRI is able to detect residual disease among most patients undergoing re-excision. False-positive results may be caused by inflammatory processes that resemble residual disease.
BACKGROUND: The accuracy of magnetic resonance imaging (MRI) in identifying residual disease after breast conservation therapy (BCT) is unclear. METHOD: Review of an institutional database identified patients with positive or close (<or=2 mm) margins undergoing MRI before re-excision. Histopathologic correlation was performed. RESULTS: Forty-three women underwent MRI after BCT. MRI suggested residual disease in 29 patients, of whom 20 (69%) had residual carcinoma pathologically. Nine patients had false-positive MRI as seen by benign pathology findings. Fourteen MRIs indicated no residual disease, of which 6 had residual disease pathologically. The sensitivity and positive predictive value of MRI was 77% and 69%, respectively. MRI conducted within 28 days of the original surgery was 85% sensitive. MRI performed after 28 days was 69% sensitive. CONCLUSIONS: MRI is able to detect residual disease among most patients undergoing re-excision. False-positive results may be caused by inflammatory processes that resemble residual disease.
Authors: Julia Krammer; Elissa R Price; Maxine S Jochelson; Elizabeth Watson; Melissa P Murray; Stefan O Schoenberg; Elizabeth A Morris Journal: Eur Radiol Date: 2017-05-31 Impact factor: 5.315
Authors: Eva C Gombos; Jagadeesan Jayender; Danielle M Richman; Diana L Caragacianu; Melissa A Mallory; Ferenc A Jolesz; Mehra Golshan Journal: Radiology Date: 2016-06-22 Impact factor: 11.105
Authors: Rita A Mukhtar; Christina Yau; Mark Rosen; Vickram J Tandon; Nola Hylton; Laura J Esserman Journal: Ann Surg Oncol Date: 2013-06-19 Impact factor: 5.344
Authors: Selvi Radhakrishna; S Agarwal; Purvish M Parikh; K Kaur; Shikha Panwar; Shelly Sharma; Ashish Dey; K K Saxena; Madhavi Chandra; Seema Sud Journal: South Asian J Cancer Date: 2018 Apr-Jun