AIM: This study aimed to find salivary enzymes and/or cytokines that would reflect periodontitis, alone or in combination with salivary microbial markers. MATERIAL AND METHODS: The salivary concentrations of elastase, lactate dehydrogenase, interleukin-1beta (IL-1beta), interleukin-6, and tumour necrosis factor-alpha, and the presence of five periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola, were analysed from salivary specimens of 165 subjects, a subpopulation of Health 2000 Health Examination Survey in Finland; 84 of the subjects had probing pocket depth (PPD) of > or =4 mm at 14 or more teeth (the advanced periodontitis group), while 81 subjects had no teeth with PPD of > or =4 mm (the control group). All subjects had at least 20 teeth and no systemic diseases. RESULTS: Among the salivary cytokines and enzymes tested, IL-1beta was the only biomarker associated with periodontitis. An association was also found with the presence of multiple periodontal pathogens. Salivary IL-1beta and the presence of multiple periodontal pathogens were associated with periodontitis at the same magnitude, when they were in the logistic regression model individually or together. CONCLUSION: We suggest that salivary IL-1beta and the presence of multiple periodontal pathogens in saliva should be studied more thoroughly as markers of periodontitis.
AIM: This study aimed to find salivary enzymes and/or cytokines that would reflect periodontitis, alone or in combination with salivary microbial markers. MATERIAL AND METHODS: The salivary concentrations of elastase, lactate dehydrogenase, interleukin-1beta (IL-1beta), interleukin-6, and tumour necrosis factor-alpha, and the presence of five periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola, were analysed from salivary specimens of 165 subjects, a subpopulation of Health 2000 Health Examination Survey in Finland; 84 of the subjects had probing pocket depth (PPD) of > or =4 mm at 14 or more teeth (the advanced periodontitis group), while 81 subjects had no teeth with PPD of > or =4 mm (the control group). All subjects had at least 20 teeth and no systemic diseases. RESULTS: Among the salivary cytokines and enzymes tested, IL-1beta was the only biomarker associated with periodontitis. An association was also found with the presence of multiple periodontal pathogens. Salivary IL-1beta and the presence of multiple periodontal pathogens were associated with periodontitis at the same magnitude, when they were in the logistic regression model individually or together. CONCLUSION: We suggest that salivary IL-1beta and the presence of multiple periodontal pathogens in saliva should be studied more thoroughly as markers of periodontitis.
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