BACKGROUND: Salivary biomarkers of periodontitis were assessed longitudinally to determine response to therapy. METHODS: A 6-month case-controlled study of adults with chronic periodontitis was performed, with 33 participants receiving oral hygiene instructions (OHI) alone and 35 with scaling and root planing (SRP) combined with OHI. Saliva samples collected at week 0, 16 and 28 were analysed for interleukin (IL)-1β, IL-8, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase-8 (MMP-8), osteoprotegerin (OPG), and tumour necrosis factor-α (TNF)-α. Clinical measures of periodontal disease were recorded at each visit. RESULTS: All parameters of periodontal health improved significantly in both groups by week 16 (p<0.0001) with the SRP group demonstrating greater benefit at week 16 and 28. Baseline OPG and TNF-α levels changed significantly at both follow-up visits (p<0.03), regardless of treatment group. IL-1β and MMP-8 levels decreased significantly from baseline (p<0.04) in the SRP group only. OPG, MMP-8, and MIP-1α were significantly reduced in responders compared with non-responders (p=0.04, 0.01, 0.05, respectively). In receiver-operating characteristic analyses, MMP-8 produced the highest area under the curve (0.7; p=0.01). CONCLUSION: Salivary levels of IL-1β, MMP-8, OPG, and MIP-1α reflected disease severity and response to therapy suggesting their potential utility for monitoring periodontal disease status.
BACKGROUND: Salivary biomarkers of periodontitis were assessed longitudinally to determine response to therapy. METHODS: A 6-month case-controlled study of adults with chronic periodontitis was performed, with 33 participants receiving oral hygiene instructions (OHI) alone and 35 with scaling and root planing (SRP) combined with OHI. Saliva samples collected at week 0, 16 and 28 were analysed for interleukin (IL)-1β, IL-8, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase-8 (MMP-8), osteoprotegerin (OPG), and tumour necrosis factor-α (TNF)-α. Clinical measures of periodontal disease were recorded at each visit. RESULTS: All parameters of periodontal health improved significantly in both groups by week 16 (p<0.0001) with the SRP group demonstrating greater benefit at week 16 and 28. Baseline OPG and TNF-α levels changed significantly at both follow-up visits (p<0.03), regardless of treatment group. IL-1β and MMP-8 levels decreased significantly from baseline (p<0.04) in the SRP group only. OPG, MMP-8, and MIP-1α were significantly reduced in responders compared with non-responders (p=0.04, 0.01, 0.05, respectively). In receiver-operating characteristic analyses, MMP-8 produced the highest area under the curve (0.7; p=0.01). CONCLUSION: Salivary levels of IL-1β, MMP-8, OPG, and MIP-1α reflected disease severity and response to therapy suggesting their potential utility for monitoring periodontal disease status.
Authors: Y M Henskens; F A van der Weijden; P A van den Keijbus; E C Veerman; M F Timmerman; U van der Velden; A V Amerongen Journal: J Periodontol Date: 1996-03 Impact factor: 6.993
Authors: T Sorsa; Y Ding; T Salo; A Lauhio; O Teronen; T Ingman; H Ohtani; N Andoh; S Takeha; Y T Konttinen Journal: Ann N Y Acad Sci Date: 1994-09-06 Impact factor: 5.691
Authors: M Al-Sabbagh; A Alladah; Y Lin; R J Kryscio; M V Thomas; J L Ebersole; C S Miller Journal: J Periodontal Res Date: 2011-11-29 Impact factor: 4.419
Authors: Karolina E Kaczor-Urbanowicz; Harsh M Trivedi; Patricia O Lima; Paulo M Camargo; William V Giannobile; Tristan R Grogan; Frederico O Gleber-Netto; Yair Whiteman; Feng Li; Hyo Jung Lee; Karan Dharia; Katri Aro; Carmen Martin Carreras-Presas; Saarah Amuthan; Manjiri Vartak; David Akin; Hiba Al-Adbullah; Kanika Bembey; Perry R Klokkevold; David Elashoff; Virginia M Barnes; Rose Richter; William DeVizio; James G Masters; David T W Wong Journal: J Clin Periodontol Date: 2018-06-15 Impact factor: 8.728
Authors: Janet S Kinney; Thiago Morelli; Min Oh; Thomas M Braun; Christoph A Ramseier; Jim V Sugai; William V Giannobile Journal: J Clin Periodontol Date: 2013-12-12 Impact factor: 8.728