| Literature DB >> 19798469 |
Nóra Eros1, Márta Marschalkó, Katalin Balassa, Bernadett Hídvégi, József Szakonyi, Sándor Ilniczky, Katalin Borka, Attila Kovács, Gyula Bottlik, Judit Hársing, Judit Csomor, Agota Szepesi, András Matolcsy, Sarolta Kárpáti, Judit Demeter.
Abstract
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.Entities:
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Year: 2009 PMID： 19798469 DOI： 10.1007/s11060-009-0026-y
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130