| Literature DB >> 16153467 |
Mirjana Urosevic1, Curdin Conrad, Jivko Kamarashev, Kenji Asagoe, Antonio Cozzio, Günter Burg, Reinhard Dummer.
Abstract
CD4+CD56+ hematodermic neoplasms (HNs) with initial presentation in the skin are characterized by highly aggressive behavior and poor prognosis. Recent studies indicate that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers, may be of plasmacytoid dendritic cell (pDC) origin. We undertook a study to assess the expression of several pDC-associated molecules on a series of 5 CD4+CD56+ HN cases. CD123 was expressed in all 5 cases, with some heterogeneity in individual cases. All but one case revealed fine membranous BDCA-2 staining of the dermal infiltrate. pDC-like phenotype of the malignant infiltrating cells was confirmed by costaining of BDCA-2+ cells with CD123 and CD4. MxA protein, representing the surrogate marker for lesional type I interferon activity, was expressed in 4 of 5 evaluated cases. Our findings further substantiate the putative pDC origin of CD4+CD56+ HNs.Entities:
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Year: 2005 PMID： 16153467 DOI： 10.1016/j.humpath.2005.07.002
Source DB: PubMed Journal: Hum Pathol ISSN： 0046-8177 Impact factor: 3.466