| Literature DB >> 19793819 |
Gordon Sandford1, Young Bong Choi, John Nicholas.
Abstract
The human herpesvirus 8 (HHV-8) viral G protein-coupled receptor (vGPCR) has been implicated in virus-associated disease pathogenesis due principally to its ability to induce the production of angiogenic cytokines involved in this process. However, the role of the vGPCR in normal virus biology is understudied and remains unknown. Here we provide evidence from vGPCR gene knockout and depletion experiments that vGPCR is a positive regulator of HHV-8 productive replication and, through experimental utilization of Galpha-coupling variants of vGPCR, that signaling via Galpha(q) activation and targeted mitogen-activated protein kinase pathways is of particular relevance to this activity.Entities:
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Year: 2009 PMID： 19793819 PMCID： PMC2786835 DOI： 10.1128/JVI.01399-09
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103