Literature DB >> 1979059

Linkage mapping of the highly informative DNA marker D21S156 to human chromosome 21 using a polymorphic GT dinucleotide repeat.

J G Lewis1, J L Weber, M B Petersen, S A Slaugenhaupt, A Kwitek, P E May, A C Warren, A Chakravarti, S E Antonarakis.   

Abstract

A (GT)n repeat within the anonymous DNA sequence D21S156 was shown to be highly polymorphic in DNA from members of the 40 CEPH families. At least 12 alleles of this locus were recognized by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction (PCR) using primers flanking the (GT)n repeat. The polymorphism information content was 0.82. PCR amplification of DNA from somatic cell hybrid lines mapped D21S156 to human chromosome 21 and linkage analysis localized this marker close to the loci ETS2, D21S3, and HMG14 on chromosomal band 21q22.3. This polymorphism is highly informative and can serve as an anchor locus for human chromosome 21.

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Year:  1990        PMID： 1979059     DOI： 10.1016/0888-7543(90)90300-j

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  12 in total

1.  Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.

Authors:  M B Peterson; M Frantzen; S E Antonarakis; A C Warren; C Van Broeckhoven; A Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

2.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

3.  No evidence for a paternal interchromosomal effect from analysis of the origin of nondisjunction in Down syndrome patients with concomitant familial chromosome rearrangements.

Authors:  A A Schinzel; P A Adelsberger; F Binkert; S Basaran; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

4.  An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.

Authors:  C Hayward; J Livingstone; S Holloway; W A Liston; D J Brock
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

5.  Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome.

Authors:  M B Petersen; A A Schinzel; F Binkert; L Tranebjaerg; M Mikkelsen; F A Collins; E P Economou; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

6.  Linkage mapping of D21S171 to the distal long arm of human chromosome 21 using a polymorphic (AC)n dinucleotide repeat.

Authors:  M B Petersen; J L Weber; S A Slaugenhaupt; A E Kwitek; M G McInnis; A Chakravarti; S E Antonarakis
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

7.  No evidence for uniparental disomy as a common cause of Sotos syndrome.

Authors:  M Smith; P Fullwood; Y Qi; S Palmer; M Upadhyaya; T Cole
Journal:  J Med Genet       Date:  1997-01       Impact factor: 6.318

8.  A large, dominant pedigree of atrioventricular septal defect (AVSD): exclusion from the Down syndrome critical region on chromosome 21.

Authors:  L Wilson; A Curtis; J R Korenberg; R D Schipper; L Allan; G Chenevix-Trench; A Stephenson; J Goodship; J Burn
Journal:  Am J Hum Genet       Date:  1993-12       Impact factor: 11.025

9.  Mechanisms of ring chromosome formation in 11 cases of human ring chromosome 21.

Authors:  M J McGinniss; H H Kazazian; G Stetten; M B Petersen; H Boman; E Engel; F Greenberg; J M Hertz; A Johnson; Z Laca
Journal:  Am J Hum Genet       Date:  1992-01       Impact factor: 11.025

10.  Cytogenetic, FISH and DNA studies in 11 individuals from a family with two siblings with dup(21q) Down syndrome.

Authors:  O Bartsch; U König; M B Petersen; H Poulsen; M Mikkelsen; F Palau; F Prieto; E Schwinger
Journal:  Hum Genet       Date:  1993-09       Impact factor: 4.132
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