Literature DB >> 1979049

DNA sequence polymorphisms in Alu repeats.

M Orita1, T Sekiya, K Hayashi.   

Abstract

We have developed an efficient method for detection of sequence differences in genomic DNA based on a new principle (M. Orita et al., 1989, Genomics 5: 874-879). Using this method, we show here that approximately half the Alu repeats interspersed in the human genome are significantly polymorphic. Analysis of Alu repeat polymorphism should be useful in construction of a high-resolution map and also in identifying genotypes of individuals for clinical and other purposes because the repeats are ubiquitous and the technique for their detection is simple.

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Year:  1990        PMID： 1979049     DOI： 10.1016/0888-7543(90)90282-y

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  25 in total

1.  Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP.

Authors:  G Sarkar; H S Yoon; S S Sommer
Journal:  Nucleic Acids Res       Date:  1992-02-25       Impact factor: 16.971

2.  Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s).

Authors:  P V Danenberg; T Horikoshi; M Volkenandt; K Danenberg; H J Lenz; L C Shea; A P Dicker; A Simoneau; P A Jones; J R Bertino
Journal:  Nucleic Acids Res       Date:  1992-02-11       Impact factor: 16.971

3.  Detection of multiallele polymorphisms within gene sequences by GC-clamped denaturing gradient gel electrophoresis.

Authors:  V C Sheffield; J S Beck; B Nichols; A Cousineau; A C Lidral; E M Stone
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

4.  3' Alu PCR: a simple and rapid method to isolate human polymorphic markers.

Authors:  J P Charlieu; A M Laurent; D A Carter; M Bellis; G Roizès
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

5.  Single-strand conformational polymorphisms (SSCP): detection of useful polymorphisms at the dystrophin locus.

Authors:  E Zietkiewicz; D Sinnett; C Richer; G Mitchell; M Vanasse; D Labuda
Journal:  Hum Genet       Date:  1992-06       Impact factor: 4.132

6.  Genetic and physical mapping on chromosome 4 narrows the localization of the gene for facioscapulohumeral muscular dystrophy (FSHD).

Authors:  K A Mills; K H Buetow; Y Xu; T M Ritty; K D Mathews; S E Bodrug; C Wijmenga; I Balazs; J C Murray
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

7.  Identification of polymorphisms by genomic denaturing gradient gel electrophoresis: application to the proximal region of human chromosome 21.

Authors:  M Burmeister; G diSibio; D R Cox; R M Myers
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

8.  Distribution and frequency of a polymorphic Alu insertion at the plasminogen activator locus in humans.

Authors:  S A Tishkoff; G Ruano; J R Kidd; K K Kidd
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

9.  Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin-dependent diabetes.

Authors:  D E Wilson; A Hata; L K Kwong; A Lingam; J Shuhua; D N Ridinger; C Yeager; K C Kaltenborn; P H Iverius; J M Lalouel
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

10.  A 530kb YAC contig tightly linked to the Friedreich ataxia locus contains five CpG clusters and a new highly polymorphic microsatellite.

Authors:  R Fujita; G Sirugo; F Duclos; H Abderrahim; D Le Paslier; D Cohen; B H Brownstein; D Schlessinger; J L Mandel; M Koenig
Journal:  Hum Genet       Date:  1992-07       Impact factor: 4.132
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