| Literature DB >> 19788328 |
Karavadhi Surendra1, E J Corey.
Abstract
The first enantioselective synthesis of lupeol has been developed by applying two carefully crafted cation-pi cyclization stages to generate the pentacyclic structure with complete stereocontrol. The synthesis (Scheme 1) is noteworthy because of its brevity and also because it solves a longstanding problem in the field of natural product synthesis.Entities:
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Year: 2009 PMID： 19788328 DOI： 10.1021/ja906335u
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419